Research ArticleMinireview—A Latin American Perspective On G Protein-Coupled Receptors
Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment
José Vázquez-Prado, Ismael Bracho-Valdés, Rodolfo Daniel Cervantes-Villagrana and Guadalupe Reyes-Cruz
Molecular Pharmacology November 2016, 90 (5) 573-586; DOI: https://doi.org/10.1124/mol.116.105338
José Vázquez-Prado
Departments of Pharmacology (J.V.-P., R.D.C.-V.) and Cell Biology (G.R.-C.). CINVESTAV-IPN, Mexico City, and Department of Pharmacology (I.B.-V.), School of Medicine, UABC, Mexicali, B.C., Mexico
Ismael Bracho-Valdés
Departments of Pharmacology (J.V.-P., R.D.C.-V.) and Cell Biology (G.R.-C.). CINVESTAV-IPN, Mexico City, and Department of Pharmacology (I.B.-V.), School of Medicine, UABC, Mexicali, B.C., Mexico
Rodolfo Daniel Cervantes-Villagrana
Departments of Pharmacology (J.V.-P., R.D.C.-V.) and Cell Biology (G.R.-C.). CINVESTAV-IPN, Mexico City, and Department of Pharmacology (I.B.-V.), School of Medicine, UABC, Mexicali, B.C., Mexico
Guadalupe Reyes-Cruz
Departments of Pharmacology (J.V.-P., R.D.C.-V.) and Cell Biology (G.R.-C.). CINVESTAV-IPN, Mexico City, and Department of Pharmacology (I.B.-V.), School of Medicine, UABC, Mexicali, B.C., Mexico

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Research ArticleMinireview—A Latin American Perspective On G Protein-Coupled Receptors
Gβγ Pathways in Oncogenic GPCR Signaling
José Vázquez-Prado, Ismael Bracho-Valdés, Rodolfo Daniel Cervantes-Villagrana and Guadalupe Reyes-Cruz
Molecular Pharmacology November 1, 2016, 90 (5) 573-586; DOI: https://doi.org/10.1124/mol.116.105338
Research ArticleMinireview—A Latin American Perspective On G Protein-Coupled Receptors
Gβγ Pathways in Oncogenic GPCR Signaling
José Vázquez-Prado, Ismael Bracho-Valdés, Rodolfo Daniel Cervantes-Villagrana and Guadalupe Reyes-Cruz
Molecular Pharmacology November 1, 2016, 90 (5) 573-586; DOI: https://doi.org/10.1124/mol.116.105338
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- Article
- Visual Overview
- Abstract
- Introduction
- Protumoral Chemotactic Agonists
- Availability of Gβγ for Chemotactic Signaling
- P-Rex1 as a Potential Chemotactic Scaffold
- Gβγ/PI3K/mTORC2/P-Rex1 Axis in Oncogenesis
- Endosomes as Platforms of Gβγ Signaling
- Gβγ Activates ERK-Signaling Cascades
- Inhibition of Gβγ Signaling Offers Pharmacologic Potential in Cancer Treatment
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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