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Research ArticleMinireview—A Latin American Perspective On G Protein-Coupled Receptors

Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences

Paula G. Slater, Hector E. Yarur and Katia Gysling
Molecular Pharmacology November 2016, 90 (5) 627-632; DOI: https://doi.org/10.1124/mol.116.104927
Paula G. Slater
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile
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Hector E. Yarur
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile
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Katia Gysling
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile
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Abstract

The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and anxiety disorders such as depression, acts through G-protein–coupled receptors (GPCRs) known as type-1 and type-2 CRF receptors. The purpose of this review is to highlight recent advances in the interactions of CRF receptors with other GPCRs and non-GPCR proteins and their associated functional consequences. A better understanding of these interactions may generate new pharmacological alternatives for the treatment of addiction and stress-related disorders.

Footnotes

    • Received April 26, 2016.
    • Accepted September 8, 2016.
  • ↵1 P.G.S. and H.E.Y. contributed equally to this work.

  • This work was supported by FONDECYT (Grant 1150244) and by CONICYT Ph.D. fellowships to P.G.S. and H.E.Y.

  • dx.doi.org/10.1124/mol.116.104927.

  • Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 90 (5)
Molecular Pharmacology
Vol. 90, Issue 5
1 Nov 2016
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Research ArticleMinireview—A Latin American Perspective On G Protein-Coupled Receptors

CRF Receptor’s Interacting Proteins

Paula G. Slater, Hector E. Yarur and Katia Gysling
Molecular Pharmacology November 1, 2016, 90 (5) 627-632; DOI: https://doi.org/10.1124/mol.116.104927

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Research ArticleMinireview—A Latin American Perspective On G Protein-Coupled Receptors

CRF Receptor’s Interacting Proteins

Paula G. Slater, Hector E. Yarur and Katia Gysling
Molecular Pharmacology November 1, 2016, 90 (5) 627-632; DOI: https://doi.org/10.1124/mol.116.104927
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