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Research ArticleMinireview—A Latin American Perspective On G Protein-Coupled Receptors

Monogenic and Monoallelic Expression of Odorant Receptors

Maíra H. Nagai, Lucia Maria Armelin-Correa and Bettina Malnic
Molecular Pharmacology November 2016, 90 (5) 633-639; DOI: https://doi.org/10.1124/mol.116.104745
Maíra H. Nagai
Department of Biochemistry, University of São Paulo, São Paulo, Brazil
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Lucia Maria Armelin-Correa
Department of Biochemistry, University of São Paulo, São Paulo, Brazil
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Bettina Malnic
Department of Biochemistry, University of São Paulo, São Paulo, Brazil
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Abstract

Odorant receptors (ORs) belong to a large gene family of rhodopsin-like G protein–coupled receptors (GPCRs). The mouse OR gene family is composed of ∼1000 OR genes, and the human OR gene family is composed of ∼400 OR genes. The OR genes are spread throughout the genome, and can be found in clusters or as solitary genes in almost all chromosomes. These chemosensory GPCRs are expressed in highly specialized cells, the olfactory sensory neurons of the nose. Each one of these neurons expresses a single OR gene out of the complete repertoire of genes. In addition, only one of the two homologous alleles of the chosen OR gene, the maternal or the paternal, is expressed per neuron. Here we review recent findings that help to elucidate the mechanisms underlying monogenic and monoallelic expression of OR genes.

Footnotes

    • Received April 13, 2016.
    • Accepted August 31, 2016.
  • This study was supported by a grant from Fundação de Amparo à Pesquisa do Estado de São Paulo [FAPESP #11/51604-8].

  • dx.doi.org/10.1124/mol.116.104745.

  • Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 90 (5)
Molecular Pharmacology
Vol. 90, Issue 5
1 Nov 2016
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Research ArticleMinireview—A Latin American Perspective On G Protein-Coupled Receptors

Odorant Receptor Gene Expression

Maíra H. Nagai, Lucia Maria Armelin-Correa and Bettina Malnic
Molecular Pharmacology November 1, 2016, 90 (5) 633-639; DOI: https://doi.org/10.1124/mol.116.104745

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Research ArticleMinireview—A Latin American Perspective On G Protein-Coupled Receptors

Odorant Receptor Gene Expression

Maíra H. Nagai, Lucia Maria Armelin-Correa and Bettina Malnic
Molecular Pharmacology November 1, 2016, 90 (5) 633-639; DOI: https://doi.org/10.1124/mol.116.104745
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  • Article
    • Visual Overview
    • Abstract
    • Introduction
    • Monoallelic Expression of OR Genes
    • Initiation of OR Gene Choice
    • Stabilization of OR Gene Choice
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