Table of Contents

Articles

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  Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics

  Ni Li, Xiao Wang, Yanni Xu, Yuan Lin, Ningyu Zhu, Peng Liu, Duo Lu and Shuyi Si

  Molecular Pharmacology April 2017, 91 (4) 264-276; DOI: https://doi.org/10.1124/mol.116.105213
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  Lacosamide Inhibition of Nav1.7 Voltage-Gated Sodium Channels: Slow Binding to Fast-Inactivated States

  Sooyeon Jo and Bruce P. Bean

  Molecular Pharmacology April 2017, 91 (4) 277-286; DOI: https://doi.org/10.1124/mol.116.106401
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  Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function

  Rithwik Ramachandran, Koichiro Mihara, Pierre Thibeault, Christina M. Vanderboor, Björn Petri, Mahmoud Saifeddine, Michel Bouvier and Morley D. Hollenberg

  Molecular Pharmacology April 2017, 91 (4) 287-295; DOI: https://doi.org/10.1124/mol.116.106526
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  Protein Kinase C Activation Promotes α_1B-Adrenoceptor Internalization and Late Endosome Trafficking through Rab9 Interaction. Role in Heterologous Desensitization

  Marco A. Alfonzo-Méndez, David A. Hernández-Espinosa, Gabriel Carmona-Rosas, M. Teresa Romero-Ávila, Guadalupe Reyes-Cruz and J. Adolfo García-Sáinz

  Molecular Pharmacology April 2017, 91 (4) 296-306; DOI: https://doi.org/10.1124/mol.116.106583
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  Trim13 Potentiates Toll-Like Receptor 2–Mediated Nuclear Factor κB Activation via K29-Linked Polyubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6

  Bin Huang and Suk-Hwan Baek

  Molecular Pharmacology April 2017, 91 (4) 307-316; DOI: https://doi.org/10.1124/mol.116.106716
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  Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy

  Wenjuan Chen, Anel Tankovic, Pieter B. Burger, Hirofumi Kusumoto, Stephen F. Traynelis and Hongjie Yuan

  Molecular Pharmacology April 2017, 91 (4) 317-330; DOI: https://doi.org/10.1124/mol.116.106781
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  AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay

  Xiulei Mo, Qi Qi, Andrei A. Ivanov, Qiankun Niu, Yin Luo, Jonathan Havel, Russell Goetze, Sydney Bell, Carlos S. Moreno, Lee A.D. Cooper, Margaret A. Johns, Fadlo R. Khuri, Yuhong Du and Haian Fu

  Molecular Pharmacology April 2017, 91 (4) 339-347; DOI: https://doi.org/10.1124/mol.116.107623
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  A New Molecular Mechanism To Engineer Protean Agonism at a G Protein–Coupled Receptor

  Anna De Min, Carlo Matera, Andreas Bock, Janine Holze, Jessica Kloeckner, Mathias Muth, Christian Traenkle, Marco De Amici, Terry Kenakin, Ulrike Holzgrabe, Clelia Dallanoce, Evi Kostenis, Klaus Mohr and Ramona Schrage

  Molecular Pharmacology April 2017, 91 (4) 348-356; DOI: https://doi.org/10.1124/mol.116.107276
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  Epigenetic Activation of μ-Opioid Receptor Gene via Increased Expression and Function of Mitogen- and Stress-Activated Protein Kinase 1

  Yadav Wagley, Ping-Yee Law, Li-Na Wei and Horace H. Loh

  Molecular Pharmacology April 2017, 91 (4) 357-372; DOI: https://doi.org/10.1124/mol.116.106567
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  Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling

  Emily V. Mesev, David S. Miller and Ronald E. Cannon

  Molecular Pharmacology April 2017, 91 (4) 373-382; DOI: https://doi.org/10.1124/mol.116.107169
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  Structural and Preclinical Studies of Computationally Designed Non-Nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection

  Shalley N. Kudalkar, Jagadish Beloor, Albert H. Chan, Won-Gil Lee, William L. Jorgensen, Priti Kumar and Karen S. Anderson

  Molecular Pharmacology April 2017, 91 (4) 383-391; DOI: https://doi.org/10.1124/mol.116.107755
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  Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore

  Hai M. Nguyen, Vikrant Singh, Brandon Pressly, David Paul Jenkins, Heike Wulff and Vladimir Yarov-Yarovoy

  Molecular Pharmacology April 2017, 91 (4) 392-402; DOI: https://doi.org/10.1124/mol.116.108068
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  Differential Effects of Oxytocin Receptor Antagonists, Atosiban and Nolasiban, on Oxytocin Receptor–Mediated Signaling in Human Amnion and Myometrium

  Sung Hye Kim, Oliver Pohl, Andre Chollet, Jean-Pierre Gotteland, Adam D. J. Fairhurst, Phillip R. Bennett and Vasso Terzidou

  Molecular Pharmacology April 2017, 91 (4) 403-415; DOI: https://doi.org/10.1124/mol.116.106013
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  Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor

  Zara Y. Weinberg, Amanda S. Zajac, Tiffany Phan, Daniel J. Shiwarski and Manojkumar A. Puthenveedu

  Molecular Pharmacology April 2017, 91 (4) 416-427; DOI: https://doi.org/10.1124/mol.116.106633
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  Divergent Mechanisms Leading to Signaling Dysfunction in Embryonic Muscle by Bisphenol A and Tetrabromobisphenol A

  Rui Zhang and Isaac N. Pessah

  Molecular Pharmacology April 2017, 91 (4) 428-436; DOI: https://doi.org/10.1124/mol.116.107342