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Molecular Pharmacology

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Research ArticleArticle

Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site

Maja Jessen, Kristen Frederiksen, Feng Yi, Rasmus P. Clausen, Kasper B. Hansen, Hans Bräuner-Osborne, Paul Kilburn and Anders Damholt
Molecular Pharmacology August 2017, 92 (2) 151-161; DOI: https://doi.org/10.1124/mol.117.108944
Maja Jessen
Department of Molecular Screening, H. Lundbeck A/S, Valby, Denmark (M.J., K.F., A.D.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (M.J., R.P.C., H.B.-O.); Department of Medicinal Chemistry 1, H. Lundbeck A/S, Valby, Denmark (P.K.); Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (F.Y., K.B.H.)
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Kristen Frederiksen
Department of Molecular Screening, H. Lundbeck A/S, Valby, Denmark (M.J., K.F., A.D.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (M.J., R.P.C., H.B.-O.); Department of Medicinal Chemistry 1, H. Lundbeck A/S, Valby, Denmark (P.K.); Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (F.Y., K.B.H.)
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Feng Yi
Department of Molecular Screening, H. Lundbeck A/S, Valby, Denmark (M.J., K.F., A.D.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (M.J., R.P.C., H.B.-O.); Department of Medicinal Chemistry 1, H. Lundbeck A/S, Valby, Denmark (P.K.); Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (F.Y., K.B.H.)
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Rasmus P. Clausen
Department of Molecular Screening, H. Lundbeck A/S, Valby, Denmark (M.J., K.F., A.D.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (M.J., R.P.C., H.B.-O.); Department of Medicinal Chemistry 1, H. Lundbeck A/S, Valby, Denmark (P.K.); Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (F.Y., K.B.H.)
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Kasper B. Hansen
Department of Molecular Screening, H. Lundbeck A/S, Valby, Denmark (M.J., K.F., A.D.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (M.J., R.P.C., H.B.-O.); Department of Medicinal Chemistry 1, H. Lundbeck A/S, Valby, Denmark (P.K.); Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (F.Y., K.B.H.)
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Hans Bräuner-Osborne
Department of Molecular Screening, H. Lundbeck A/S, Valby, Denmark (M.J., K.F., A.D.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (M.J., R.P.C., H.B.-O.); Department of Medicinal Chemistry 1, H. Lundbeck A/S, Valby, Denmark (P.K.); Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (F.Y., K.B.H.)
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Paul Kilburn
Department of Molecular Screening, H. Lundbeck A/S, Valby, Denmark (M.J., K.F., A.D.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (M.J., R.P.C., H.B.-O.); Department of Medicinal Chemistry 1, H. Lundbeck A/S, Valby, Denmark (P.K.); Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (F.Y., K.B.H.)
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Anders Damholt
Department of Molecular Screening, H. Lundbeck A/S, Valby, Denmark (M.J., K.F., A.D.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (M.J., R.P.C., H.B.-O.); Department of Medicinal Chemistry 1, H. Lundbeck A/S, Valby, Denmark (P.K.); Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (F.Y., K.B.H.)
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Article Information

vol. 92 no. 2 151-161
DOI 
https://doi.org/10.1124/mol.117.108944
PubMed 
28588066

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 31, 2017
  • Accepted June 1, 2017
  • Published online July 6, 2017.

Article Versions

  • Earlier version (June 6, 2017 - 07:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Maja Jessen,
  2. Kristen Frederiksen,
  3. Feng Yi,
  4. Rasmus P. Clausen,
  5. Kasper B. Hansen,
  6. Hans Bräuner-Osborne,
  7. Paul Kilburn, and
  8. Anders Damholt1
  1. Department of Molecular Screening, H. Lundbeck A/S, Valby, Denmark (M.J., K.F., A.D.); Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (M.J., R.P.C., H.B.-O.); Department of Medicinal Chemistry 1, H. Lundbeck A/S, Valby, Denmark (P.K.); Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana (F.Y., K.B.H.)
  1. Address correspondence to:
    Dr. Kristen Frederiksen, Department of Molecular Screening, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark. E-mail: krf{at}lundbeck.com or Dr. Kasper B. Hansen, Department of Biomedical and Pharmaceutical Sciences, University of Montana, 32 Campus Dr, Missoula, Montana 59812. E-mail: kasper.hansen{at}mso.umt.edu
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Molecular Pharmacology: 92 (2)
Molecular Pharmacology
Vol. 92, Issue 2
1 Aug 2017
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Research ArticleArticle

AICP Is a GluN2C-Selective NMDA Receptor Superagonist

Maja Jessen, Kristen Frederiksen, Feng Yi, Rasmus P. Clausen, Kasper B. Hansen, Hans Bräuner-Osborne, Paul Kilburn and Anders Damholt
Molecular Pharmacology August 1, 2017, 92 (2) 151-161; DOI: https://doi.org/10.1124/mol.117.108944

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Research ArticleArticle

AICP Is a GluN2C-Selective NMDA Receptor Superagonist

Maja Jessen, Kristen Frederiksen, Feng Yi, Rasmus P. Clausen, Kasper B. Hansen, Hans Bräuner-Osborne, Paul Kilburn and Anders Damholt
Molecular Pharmacology August 1, 2017, 92 (2) 151-161; DOI: https://doi.org/10.1124/mol.117.108944
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