Table of Contents

Articles

• Open Access

  NO-Sensitive Guanylate Cyclase Isoforms NO-GC1 and NO-GC2 Contribute to Noise-Induced Inner Hair Cell Synaptopathy

  Dorit Möhrle, Katrin Reimann, Steffen Wolter, Markus Wolters, Ksenya Varakina, Evanthia Mergia, Nicole Eichert, Hyun-Soon Geisler, Peter Sandner, Peter Ruth, Andreas Friebe, Robert Feil, Ulrike Zimmermann, Doris Koesling, Marlies Knipper and Lukas Rüttiger

  Molecular Pharmacology October 2017, 92 (4) 375-388; DOI: https://doi.org/10.1124/mol.117.108548
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  A Novel Selective Inverse Agonist of the CB₂ Receptor as a Radiolabeled Tool Compound for Kinetic Binding Studies

  Andrea Martella, Huub Sijben, Arne C. Rufer, Uwe Grether, Juergen Fingerle, Christoph Ullmer, Thomas Hartung, Adriaan P. IJzerman, Mario van der Stelt and Laura H. Heitman

  Molecular Pharmacology October 2017, 92 (4) 389-400; DOI: https://doi.org/10.1124/mol.117.108605
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  Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis

  Muhammad Imran Sohail, Diethart Schmid, Katrin Wlcek, Matthias Spork, Gergely Szakács, Michael Trauner, Thomas Stockner and Peter Chiba

  Molecular Pharmacology October 2017, 92 (4) 401-413; DOI: https://doi.org/10.1124/mol.117.108688
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  Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor

  Zhihui Zheng, Zanmei Zhao, Shuqiang Li, Xinhua Lu, Mengxi Jiang, Jie Lin, Yunqi An, Yang Xie, Meishu Xu, Wenbin Shen, Grace L. Guo, Yixian Huang, Song Li, Xuexia Zhang and Wen Xie

  Molecular Pharmacology October 2017, 92 (4) 425-436; DOI: https://doi.org/10.1124/mol.117.108829
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  Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3

  Alison Gardner, Wei Wu, Steven Thomson, Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger and Michael C. Sanguinetti

  Molecular Pharmacology October 2017, 92 (4) 437-450; DOI: https://doi.org/10.1124/mol.117.108886
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  Human Missense Mutations in Regulator of G Protein Signaling 2 Affect the Protein Function Through Multiple Mechanisms

  Hoa T.N. Phan, Benita Sjögren and Richard R. Neubig

  Molecular Pharmacology October 2017, 92 (4) 451-458; DOI: https://doi.org/10.1124/mol.117.109215
• Open Access

  Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3

  Anastasios Chanalaris, Christine Doherty, Brian D. Marsden, Gabriel Bambridge, Stephen P. Wren, Hideaki Nagase and Linda Troeberg

  Molecular Pharmacology October 2017, 92 (4) 459-468; DOI: https://doi.org/10.1124/mol.117.109397
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  Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121)

  Brandon M. Brown, Heesung Shim, Miao Zhang, Vladimir Yarov-Yarovoy and Heike Wulff

  Molecular Pharmacology October 2017, 92 (4) 469-480; DOI: https://doi.org/10.1124/mol.117.109421
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  Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells

  Emilia Kansanen, Suvi M. Kuosmanen, Anna-Kaisa Ruotsalainen, Heidi Hynynen and Anna-Liisa Levonen

  Molecular Pharmacology October 2017, 92 (4) 481-490; DOI: https://doi.org/10.1124/mol.117.109751
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  Splice Variants of pH-Sensitive Chloride Channel Identify a Key Determinant of Ivermectin Sensitivity in the Larvae of the Silkworm Bombyx mori

  Daiki Okuhara, Shogo Furutani, Katsuhiko Ito, Makoto Ihara and Kazuhiko Matsuda

  Molecular Pharmacology October 2017, 92 (4) 491-499; DOI: https://doi.org/10.1124/mol.117.109199