Table of Contents

Articles

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  ABIN-1 Negatively Regulates μ-Opioid Receptor Function

  Peilan Zhou, Jiebing Jiang, Hui Yan, Yulei Li, Junru Zhao, Xiao Wang, Ruibin Su and Zehui Gong

  Molecular Pharmacology February 2018, 93 (2) 36-48; DOI: https://doi.org/10.1124/mol.117.109009
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  Slowly Signaling G Protein–Biased CB₂ Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence

  Xiaoyan Lin, Amey S. Dhopeshwarkar, Megan Huibregtse, Ken Mackie and Andrea G. Hohmann

  Molecular Pharmacology February 2018, 93 (2) 49-62; DOI: https://doi.org/10.1124/mol.117.109355
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  Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity

  Yi Lu, Weili Zheng, Shengchen Lin, Fusheng Guo, Yanlin Zhu, Yijuan Wei, Xi Liu, Shikai Jin, Lihua Jin and Yong Li

  Molecular Pharmacology February 2018, 93 (2) 63-72; DOI: https://doi.org/10.1124/mol.117.109900
• Open Access

  Irreversible Activation and Stabilization of Soluble Guanylate Cyclase by the Protoporphyrin IX Mimetic Cinaciguat

  Alexander Kollau, Marissa Opelt, Gerald Wölkart, Antonius C. F. Gorren, Michael Russwurm, Doris Koesling, Bernd Mayer and Astrid Schrammel

  Molecular Pharmacology February 2018, 93 (2) 73-78; DOI: https://doi.org/10.1124/mol.117.109918
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  Molecular Imaging of GLUT1 and GLUT5 in Breast Cancer: A Multitracer Positron Emission Tomography Imaging Study in Mice

  Melinda Wuest, Ingrit Hamann, Vincent Bouvet, Darryl Glubrecht, Alison Marshall, Brendan Trayner, Olivier-Mohamad Soueidan, Daniel Krys, Michael Wagner, Chris Cheeseman, Frederick West and Frank Wuest

  Molecular Pharmacology February 2018, 93 (2) 79-89; DOI: https://doi.org/10.1124/mol.117.110007
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  GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC₅₀ and Basal Activity

  Gustav Akk, Daniel J. Shin, Allison L. Germann and Joe Henry Steinbach

  Molecular Pharmacology February 2018, 93 (2) 90-100; DOI: https://doi.org/10.1124/mol.117.110569
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  Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo

  Morrie Lam, Natalia Mast and Irina A. Pikuleva

  Molecular Pharmacology February 2018, 93 (2) 101-108; DOI: https://doi.org/10.1124/mol.117.110742
• Open Access

  S1P₁ Modulator-Induced G_αi Signaling and β-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo

  Magdalena Birker-Robaczewska, Martin Bolli, Markus Rey, Ruben de Kanter, Christopher Kohl, Cyrille Lescop, Maxime Boucher, Sylvie Poirey, Beat Steiner and Oliver Nayler

  Molecular Pharmacology February 2018, 93 (2) 109-118; DOI: https://doi.org/10.1124/mol.117.109140
• Open Access

  Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model

  Joseph Newcombe, Anna Chatzidaki, Tom D. Sheppard, Maya Topf and Neil S. Millar

  Molecular Pharmacology February 2018, 93 (2) 128-140; DOI: https://doi.org/10.1124/mol.117.110551
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  The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor

  Thomas M. Kaiser, Steven A. Kell, Hirofumi Kusumoto, Gil Shaulsky, Subhrajit Bhattacharya, Matthew P. Epplin, Katie L. Strong, Eric J. Miller, Bryan D. Cox, David S. Menaldino, Dennis C. Liotta, Stephen F. Traynelis and Pieter B. Burger

  Molecular Pharmacology February 2018, 93 (2) 141-156; DOI: https://doi.org/10.1124/mol.117.110940
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  Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors

  Kathryn E. Livingston, M. Alexander Stanczyk, Neil T. Burford, Andrew Alt, Meritxell Canals and John R. Traynor

  Molecular Pharmacology February 2018, 93 (2) 157-167; DOI: https://doi.org/10.1124/mol.117.109561
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  (Z)-2-(3,4-Dichlorophenyl)-3-(1H-Pyrrol-2-yl)Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway

  Jayne Gilbert, Geoffry N. De Iuliis, Mark Tarleton, Adam McCluskey and Jennette A. Sakoff

  Molecular Pharmacology February 2018, 93 (2) 168-177; DOI: https://doi.org/10.1124/mol.117.109827
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  Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABA_A Receptors

  Daniel J. Shin, Allison L. Germann, Alexander D. Johnson, Stuart A. Forman, Joe Henry Steinbach and Gustav Akk

  Molecular Pharmacology February 2018, 93 (2) 178-189; DOI: https://doi.org/10.1124/mol.117.110403