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Slowly Signaling G Protein–Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence

Xiaoyan Lin, Amey S. Dhopeshwarkar, Megan Huibregtse, Ken Mackie and Andrea G. Hohmann
Molecular Pharmacology February 2018, 93 (2) 49-62; DOI: https://doi.org/10.1124/mol.117.109355

Article Information

vol. 93 no. 2 49-62
DOI 
https://doi.org/10.1124/mol.117.109355
PubMed 
29192123
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 5, 2017
  • Accepted November 6, 2017
  • Published online December 28, 2017.

Article Versions

Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xiaoyan Lin,
  2. Amey S. Dhopeshwarkar,
  3. Megan Huibregtse,
  4. Ken Mackie, and
  5. Andrea G. Hohmann
  1. Psychological and Brain Sciences (X.L., A.S.D., M.H., K.M., A.G.H.), Program in Neuroscience (K.M., A.G.H.), and Gill Center for Biomolecular Science (K.M., A.G.H.), Indiana University, Bloomington, Indiana
  1. Address correspondence to:
    Andrea G. Hohmann, Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th St., Bloomington, IN 47405-7007. E-mail: hohmanna{at}indiana.edu
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Research ArticleArticle

Role of CB2 in Morphine Tolerance and Dependence

Xiaoyan Lin, Amey S. Dhopeshwarkar, Megan Huibregtse, Ken Mackie and Andrea G. Hohmann
Molecular Pharmacology February 1, 2018, 93 (2) 49-62; DOI: https://doi.org/10.1124/mol.117.109355
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