Table of Contents

Articles

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  Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors

  Anita K. Nivedha, Christofer S. Tautermann, Supriyo Bhattacharya, Sangbae Lee, Paola Casarosa, Ines Kollak, Tobias Kiechle and Nagarajan Vaidehi

  Molecular Pharmacology April 2018, 93 (4) 288-296; DOI: https://doi.org/10.1124/mol.117.110395
• Open Access

  Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo

  Ryan S. Wible, Quynh T. Tran, Samreen Fathima, Carrie H. Sutter, Thomas W. Kensler and Thomas R. Sutter

  Molecular Pharmacology April 2018, 93 (4) 297-308; DOI: https://doi.org/10.1124/mol.117.110262
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  Molecular Mechanisms of Biased and Probe-Dependent Signaling at CXC-Motif Chemokine Receptor CXCR3 Induced by Negative Allosteric Modulators

  Regine Brox, Lampros Milanos, Noureldin Saleh, Paul Baumeister, Armin Buschauer, Dagmar Hofmann, Markus R. Heinrich, Timothy Clark and Nuska Tschammer

  Molecular Pharmacology April 2018, 93 (4) 309-322; DOI: https://doi.org/10.1124/mol.117.110296
• Open Access

  Elucidation of the Binding Mode of the Carboxyterminal Region of Peptide YY to the Human Y₂ Receptor

  Bo Xu, Silvana Vasile, Søren Østergaard, Johan F. Paulsson, Jasna Pruner, Johan Åqvist, Birgitte S. Wulff, Hugo Gutiérrez-de-Terán and Dan Larhammar

  Molecular Pharmacology April 2018, 93 (4) 323-334; DOI: https://doi.org/10.1124/mol.117.110627
• Open Access

  Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance

  Marissa Opelt, Gerald Wölkart, Emrah Eroglu, Markus Waldeck-Weiermair, Roland Malli, Wolfgang F. Graier, Alexander Kollau, John T. Fassett, Astrid Schrammel, Bernd Mayer and Antonius C. F. Gorren

  Molecular Pharmacology April 2018, 93 (4) 335-343; DOI: https://doi.org/10.1124/mol.117.110783
• Open Access

  Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme

  J. Albert Abrie, Wessel J. A. Moolman, Gyles E. Cozier, Sylva L. Schwager, K. Ravi Acharya and Edward D. Sturrock

  Molecular Pharmacology April 2018, 93 (4) 344-354; DOI: https://doi.org/10.1124/mol.117.110866
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  Probing the Mechanism of Receptor Activity–Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists

  Jason M. Booe, Margaret L. Warner, Amanda M. Roehrkasse, Debbie L. Hay and Augen A. Pioszak

  Molecular Pharmacology April 2018, 93 (4) 355-367; DOI: https://doi.org/10.1124/mol.117.110916
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  Long Noncoding RNA LINC00657 Acting as a miR-590-3p Sponge to Facilitate Low Concentration Oxidized Low-Density Lipoprotein–Induced Angiogenesis

  Mei-Hua Bao, Guang-Yi Li, Xiao-Shan Huang, Liang Tang, Li-Ping Dong and Jian-Ming Li

  Molecular Pharmacology April 2018, 93 (4) 368-375; DOI: https://doi.org/10.1124/mol.117.110650
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  Allosterism within δ Opioid–κ Opioid Receptor Heteromers in Peripheral Sensory Neurons: Regulation of κ Opioid Agonist Efficacy

  Blaine A. Jacobs, Miryam M. Pando, Elaine Jennings, Teresa A. Chavera, William P. Clarke and Kelly A. Berg

  Molecular Pharmacology April 2018, 93 (4) 376-386; DOI: https://doi.org/10.1124/mol.117.109975
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  G Protein Preassembly Rescues Efficacy of W^6.48 Toggle Mutations in Neuropeptide Y₂ Receptor

  Anette Kaiser, Caroline Hempel, Lizzy Wanka, Mario Schubert, Heidi E. Hamm and Annette G. Beck-Sickinger

  Molecular Pharmacology April 2018, 93 (4) 387-401; DOI: https://doi.org/10.1124/mol.117.110544
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  Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake

  Valentin Gorboulev, Saba Rehman, Christoph M. Albert, Ursula Roth, Marleen J. Meyer, Mladen V. Tzvetkov, Thomas D. Mueller and Hermann Koepsell

  Molecular Pharmacology April 2018, 93 (4) 402-415; DOI: https://doi.org/10.1124/mol.117.110767