Article Figures & Data
Figures
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Figure 1 - Simulation of time traces for ALDH2-catalyzed NO generation from GTN
Supplemental Figure 2 - Simulated time traces for ALDH2-catalyzed NO generation from GTN withparameters derived from the observed time traces
Supplemental Table 1 - Comparison between simulation and fitting parameters from Fig. S1a
Supplemental Table 2 - Comparison between simulation and fitting parameters from Fig. S2a
Supplemental Figure 3 - Comparison of the simulated time courses for NO generation and ALDH
oxidation by GTNSupplemental Figure 4 - Analysis of the average kinetics of formation and decay of NO
Supplemental Table 3 - Fitting parameters derived from Fig. S4
Supplemental Figure 5 - Tolerance plots for the fitting parameters of the average time course in the absence of DTT to Eq. 4
Supplemental Figure 6 - Distribution of fitting parameters for single NO time courses
Supplemental Figure 7 - Individual traces that were averaged in Fig. 1A
Supplemental Figure 8 - Individual traces that were averaged in Fig. 6A
Supplemental Figure 9 - Decrease of the NO signal in the presence of DTT upon repeated perfusion (data from Fig. 3A)
Supplemental Figure 10 - Effect of perfusion with chloralhydrate on the generation of NO from GTN
Supplemental Figure 11 - The irreversibility of loss of NO generation upon perfusion with GTN and DTT is not affected by cycloheximide
Supplemental Figure 12 - Effect of PX-12 on NO generation from GTN
References
- Supplemental Data -