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Research ArticleArticle

G Protein Preassembly Rescues Efficacy of W6.48 Toggle Mutations in Neuropeptide Y2 Receptor

Anette Kaiser, Caroline Hempel, Lizzy Wanka, Mario Schubert, Heidi E. Hamm and Annette G. Beck-Sickinger
Molecular Pharmacology April 2018, 93 (4) 387-401; DOI: https://doi.org/10.1124/mol.117.110544
Anette Kaiser
Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig University, Leipzig, Germany (A.K., C.H., L.W., M.S., A.G.B.-S.); and Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee (A.K., C.H., H.E.H.)
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Caroline Hempel
Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig University, Leipzig, Germany (A.K., C.H., L.W., M.S., A.G.B.-S.); and Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee (A.K., C.H., H.E.H.)
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Lizzy Wanka
Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig University, Leipzig, Germany (A.K., C.H., L.W., M.S., A.G.B.-S.); and Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee (A.K., C.H., H.E.H.)
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Mario Schubert
Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig University, Leipzig, Germany (A.K., C.H., L.W., M.S., A.G.B.-S.); and Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee (A.K., C.H., H.E.H.)
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Heidi E. Hamm
Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig University, Leipzig, Germany (A.K., C.H., L.W., M.S., A.G.B.-S.); and Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee (A.K., C.H., H.E.H.)
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Annette G. Beck-Sickinger
Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig University, Leipzig, Germany (A.K., C.H., L.W., M.S., A.G.B.-S.); and Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee (A.K., C.H., H.E.H.)
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Article Information

vol. 93 no. 4 387-401
DOI 
https://doi.org/10.1124/mol.117.110544
PubMed 
29436493

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 8, 2017
  • Accepted February 2, 2018
  • Published online March 6, 2018.

Article Versions

  • Earlier version (February 7, 2018 - 09:37).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anette Kaiser,
  2. Caroline Hempel,
  3. Lizzy Wanka,
  4. Mario Schubert,
  5. Heidi E. Hamm, and
  6. Annette G. Beck-Sickinger
  1. Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig University, Leipzig, Germany (A.K., C.H., L.W., M.S., A.G.B.-S.); and Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee (A.K., C.H., H.E.H.)
  1. Address correspondence to:
    Dr. Anette Kaiser, Faculty of Biosciences, Pharmacy and Psychology, Institute of Biochemistry, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany. E-mail: anette.kaiser{at}uni-leipzig.de
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Molecular Pharmacology: 93 (4)
Molecular Pharmacology
Vol. 93, Issue 4
1 Apr 2018
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Research ArticleArticle

Effector Coupling of Y2 Receptor and W6.48 Toggle Mutations

Anette Kaiser, Caroline Hempel, Lizzy Wanka, Mario Schubert, Heidi E. Hamm and Annette G. Beck-Sickinger
Molecular Pharmacology April 1, 2018, 93 (4) 387-401; DOI: https://doi.org/10.1124/mol.117.110544

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Research ArticleArticle

Effector Coupling of Y2 Receptor and W6.48 Toggle Mutations

Anette Kaiser, Caroline Hempel, Lizzy Wanka, Mario Schubert, Heidi E. Hamm and Annette G. Beck-Sickinger
Molecular Pharmacology April 1, 2018, 93 (4) 387-401; DOI: https://doi.org/10.1124/mol.117.110544
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