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Molecular Pharmacology

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Research ArticleArticle

Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake

Valentin Gorboulev, Saba Rehman, Christoph M. Albert, Ursula Roth, Marleen J. Meyer, Mladen V. Tzvetkov, Thomas D. Mueller and Hermann Koepsell
Molecular Pharmacology April 2018, 93 (4) 402-415; DOI: https://doi.org/10.1124/mol.117.110767
Valentin Gorboulev
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.)
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Saba Rehman
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.)
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Christoph M. Albert
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.)
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Ursula Roth
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.)
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Marleen J. Meyer
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.)
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Mladen V. Tzvetkov
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.)
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Thomas D. Mueller
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.)
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Hermann Koepsell
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.)
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Article Information

vol. 93 no. 4 402-415
DOI 
https://doi.org/10.1124/mol.117.110767
PubMed 
29339398

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 29, 2017
  • Accepted January 12, 2018
  • Published online March 6, 2018.

Article Versions

  • Earlier version (January 16, 2018 - 06:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Valentin Gorboulev,
  2. Saba Rehman,
  3. Christoph M. Albert,
  4. Ursula Roth,
  5. Marleen J. Meyer,
  6. Mladen V. Tzvetkov,
  7. Thomas D. Mueller, and
  8. Hermann Koepsell
  1. Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.)
  1. Address correspondence to:
    Hermann Koepsell, Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, Julius-von-Sachs-Platz 2, 97082 Würzburg, Germany. E-mail: Hermann{at}Koepsell.de
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Molecular Pharmacology: 93 (4)
Molecular Pharmacology
Vol. 93, Issue 4
1 Apr 2018
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Research ArticleArticle

Three Extracellular Inhibitors Bind to Amino Acids in OCT1

Valentin Gorboulev, Saba Rehman, Christoph M. Albert, Ursula Roth, Marleen J. Meyer, Mladen V. Tzvetkov, Thomas D. Mueller and Hermann Koepsell
Molecular Pharmacology April 1, 2018, 93 (4) 402-415; DOI: https://doi.org/10.1124/mol.117.110767

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Research ArticleArticle

Three Extracellular Inhibitors Bind to Amino Acids in OCT1

Valentin Gorboulev, Saba Rehman, Christoph M. Albert, Ursula Roth, Marleen J. Meyer, Mladen V. Tzvetkov, Thomas D. Mueller and Hermann Koepsell
Molecular Pharmacology April 1, 2018, 93 (4) 402-415; DOI: https://doi.org/10.1124/mol.117.110767
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