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High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABAA Receptors

Allison L. Germann, Daniel J. Shin, Christina R. Kuhrau, Alexander D. Johnson, Alex S. Evers and Gustav Akk
Molecular Pharmacology May 2018, 93 (5) 468-476; DOI: https://doi.org/10.1124/mol.117.111435

Article Information

vol. 93 no. 5 468-476
DOI 
https://doi.org/10.1124/mol.117.111435
PubMed 
29439087
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received December 15, 2017
  • Accepted February 7, 2018
  • Published online March 30, 2018.

Article Versions

Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Allison L. Germann,
  2. Daniel J. Shin,
  3. Christina R. Kuhrau,
  4. Alexander D. Johnson,
  5. Alex S. Evers, and
  6. Gustav Akk
  1. Department of Anesthesiology (A.L.G., D.J.S., C.R.K., A.D.J., A.S.E., G.A.) and Taylor Family Institute for Innovative Psychiatric Research (A.S.E., G.A.), Washington University School of Medicine, St. Louis, Missouri
  1. Address correspondence to:
    Gustav Akk, Department of Anesthesiology, Washington University School of Medicine, Campus Box 8054, 660 South Euclid Ave., St. Louis, MO 63110. E-mail: akk{at}morpheus.wustl.edu
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Effect of Constitutive Activity on Potentiation

Allison L. Germann, Daniel J. Shin, Christina R. Kuhrau, Alexander D. Johnson, Alex S. Evers and Gustav Akk
Molecular Pharmacology May 1, 2018, 93 (5) 468-476; DOI: https://doi.org/10.1124/mol.117.111435
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