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Molecular Pharmacology

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Research ArticleArticle

Differential Pharmacology and Binding of mGlu2 Receptor Allosteric Modulators

Daniel E. O’Brien, Douglas M. Shaw, Hyekyung P. Cho, Alan J. Cross, Steven S. Wesolowski, Andrew S. Felts, Jonas Bergare, Charles S. Elmore, Craig W. Lindsley, Colleen M. Niswender and P. Jeffrey Conn
Molecular Pharmacology May 2018, 93 (5) 526-540; DOI: https://doi.org/10.1124/mol.117.110114
Daniel E. O’Brien
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Douglas M. Shaw
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Hyekyung P. Cho
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Alan J. Cross
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Steven S. Wesolowski
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Andrew S. Felts
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Jonas Bergare
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Charles S. Elmore
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Craig W. Lindsley
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Colleen M. Niswender
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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P. Jeffrey Conn
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
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Article Information

vol. 93 no. 5 526-540
DOI 
https://doi.org/10.1124/mol.117.110114
PubMed 
29545267

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 8, 2017
  • Accepted March 12, 2018
  • Published online April 10, 2018.

Article Versions

  • Earlier version (March 15, 2018 - 07:32).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Daniel E. O’Brien,
  2. Douglas M. Shaw,
  3. Hyekyung P. Cho,
  4. Alan J. Cross,
  5. Steven S. Wesolowski,
  6. Andrew S. Felts,
  7. Jonas Bergare,
  8. Charles S. Elmore,
  9. Craig W. Lindsley,
  10. Colleen M. Niswender, and
  11. P. Jeffrey Conn
  1. Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery (D.E.O., D.M.S., H.P.C., A.S.F., C.W.L, C.M.N., P.J.C.), Vanderbilt Brain Institute (P.J.C.), and Vanderbilt Kennedy Center (C.M.N., P.J.C.), Vanderbilt University, Nashville, Tennessee; AstraZeneca Neuroscience Innovative Medicines, AstraZeneca, Cambridge, Massachusetts (A.J.C., S.S.W.); and AstraZeneca Pharmaceutical Sciences, AstraZeneca, Mölndal, Sweden (J.B., C.S.E.)
  1. Address correspondence to:
    Dr. P. Jeffrey Conn, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, 1215D Light Hall, Nashville, TN 37232. E-mail: jeff.conn{at}vanderbilt.edu
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Molecular Pharmacology: 93 (5)
Molecular Pharmacology
Vol. 93, Issue 5
1 May 2018
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Research ArticleArticle

mGlu2 Allosteric Modulator Pharmacology and Binding Sites

Daniel E. O’Brien, Douglas M. Shaw, Hyekyung P. Cho, Alan J. Cross, Steven S. Wesolowski, Andrew S. Felts, Jonas Bergare, Charles S. Elmore, Craig W. Lindsley, Colleen M. Niswender and P. Jeffrey Conn
Molecular Pharmacology May 1, 2018, 93 (5) 526-540; DOI: https://doi.org/10.1124/mol.117.110114

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Research ArticleArticle

mGlu2 Allosteric Modulator Pharmacology and Binding Sites

Daniel E. O’Brien, Douglas M. Shaw, Hyekyung P. Cho, Alan J. Cross, Steven S. Wesolowski, Andrew S. Felts, Jonas Bergare, Charles S. Elmore, Craig W. Lindsley, Colleen M. Niswender and P. Jeffrey Conn
Molecular Pharmacology May 1, 2018, 93 (5) 526-540; DOI: https://doi.org/10.1124/mol.117.110114
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