Table of Contents

Articles

• You have access

  Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance–Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator–Activated Receptor α Activation

  Le Wang, Leilei Ma, Yunfei Lin, Xing Liu, Ling Xiao, Yiting Zhang, Ye Xu, Hu Zhou and Guoyu Pan

  Molecular Pharmacology June 2018, 93 (6) 563-574; DOI: https://doi.org/10.1124/mol.117.110593
• You have access

  Inhibition of CD45 Phosphatase Activity Induces Cell Cycle Arrest and Apoptosis of CD45⁺ Lymphoid Tumors Ex Vivo and In Vivo

  Michael Perron and H. Uri Saragovi

  Molecular Pharmacology June 2018, 93 (6) 575-580; DOI: https://doi.org/10.1124/mol.117.110908
• 

  You have access

  GPR40-Mediated Gα12 Activation by Allosteric Full Agonists Highly Efficacious at Potentiating Glucose-Stimulated Insulin Secretion in Human Islets

  Marie-Laure Rives, Brian Rady, Nadia Swanson, Shuyuan Zhao, Jenson Qi, Eric Arnoult, Ivona Bakaj, Arturo Mancini, Billy Breton, S. Paul Lee, Mark R. Player and Alessandro Pocai

  Molecular Pharmacology June 2018, 93 (6) 581-591; DOI: https://doi.org/10.1124/mol.117.111369
• Open Access

  Kir Channel Blockages by Proflavine Derivatives via Multiple Modes of Interaction

  Atsushi Inanobe, Hideaki Itamochi and Yoshihisa Kurachi

  Molecular Pharmacology June 2018, 93 (6) 592-600; DOI: https://doi.org/10.1124/mol.117.111377
• You have access

  Ionotropic and Metabotropic Mechanisms of Allosteric Modulation of α7 Nicotinic Receptor Intracellular Calcium

  Justin R. King, Aman Ullah, Ellen Bak, M. Saleet Jafri and Nadine Kabbani

  Molecular Pharmacology June 2018, 93 (6) 601-611; DOI: https://doi.org/10.1124/mol.117.111401
• You have access

  Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains

  Onofrio Laselva, Steven Molinski, Valeria Casavola and Christine E. Bear

  Molecular Pharmacology June 2018, 93 (6) 612-618; DOI: https://doi.org/10.1124/mol.118.111799
• You have access

  Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms

  Andrew N. Keller, Irina Kufareva, Tracy M. Josephs, Jiayin Diao, Vyvyan T. Mai, Arthur D. Conigrave, Arthur Christopoulos, Karen J. Gregory and Katie Leach

  Molecular Pharmacology June 2018, 93 (6) 619-630; DOI: https://doi.org/10.1124/mol.118.112086
• You have access

  Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor

  Martina Stepankova, Iveta Bartonkova, Eva Jiskrova, Radim Vrzal, Sridhar Mani, Sandhya Kortagere and Zdenek Dvorak

  Molecular Pharmacology June 2018, 93 (6) 631-644; DOI: https://doi.org/10.1124/mol.118.112151
• Open Access

  Bitopic Binding Mode of an M₁ Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

  Sophie J. Bradley, Colin Molloy, Christoffer Bundgaard, Adrian J. Mogg, Karen J. Thompson, Louis Dwomoh, Helen E. Sanger, Michael D. Crabtree, Simon M. Brooke, Patrick M. Sexton, Christian C. Felder, Arthur Christopoulos, Lisa M. Broad, Andrew B. Tobin and Christopher J. Langmead

  Molecular Pharmacology June 2018, 93 (6) 645-656; DOI: https://doi.org/10.1124/mol.118.111872