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Molecular Pharmacology

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Table of Contents

June 01, 2018; Volume 93,Issue 6

Accelerated Communication

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    Thermoregulation-Independent Regulation of Sleep by Serotonin Revealed in Mice Defective in Serotonin Synthesis
    Xian Zhang, Hongming Yan, Yanjia Luo, Zili Huang and Yi Rao
    Molecular Pharmacology June 2018, 93 (6) 657-664; DOI: https://doi.org/10.1124/mol.117.111229

Articles

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    Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance–Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator–Activated Receptor α Activation
    Le Wang, Leilei Ma, Yunfei Lin, Xing Liu, Ling Xiao, Yiting Zhang, Ye Xu, Hu Zhou and Guoyu Pan
    Molecular Pharmacology June 2018, 93 (6) 563-574; DOI: https://doi.org/10.1124/mol.117.110593
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    Inhibition of CD45 Phosphatase Activity Induces Cell Cycle Arrest and Apoptosis of CD45+ Lymphoid Tumors Ex Vivo and In Vivo
    Michael Perron and H. Uri Saragovi
    Molecular Pharmacology June 2018, 93 (6) 575-580; DOI: https://doi.org/10.1124/mol.117.110908
  • GPR40-Mediated G<em>α</em>12 Activation by Allosteric Full Agonists Highly Efficacious at Potentiating Glucose-Stimulated Insulin Secretion in Human Islets
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    GPR40-Mediated Gα12 Activation by Allosteric Full Agonists Highly Efficacious at Potentiating Glucose-Stimulated Insulin Secretion in Human Islets
    Marie-Laure Rives, Brian Rady, Nadia Swanson, Shuyuan Zhao, Jenson Qi, Eric Arnoult, Ivona Bakaj, Arturo Mancini, Billy Breton, S. Paul Lee, Mark R. Player and Alessandro Pocai
    Molecular Pharmacology June 2018, 93 (6) 581-591; DOI: https://doi.org/10.1124/mol.117.111369
  • Open Access
    Kir Channel Blockages by Proflavine Derivatives via Multiple Modes of Interaction
    Atsushi Inanobe, Hideaki Itamochi and Yoshihisa Kurachi
    Molecular Pharmacology June 2018, 93 (6) 592-600; DOI: https://doi.org/10.1124/mol.117.111377
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    Ionotropic and Metabotropic Mechanisms of Allosteric Modulation of α7 Nicotinic Receptor Intracellular Calcium
    Justin R. King, Aman Ullah, Ellen Bak, M. Saleet Jafri and Nadine Kabbani
    Molecular Pharmacology June 2018, 93 (6) 601-611; DOI: https://doi.org/10.1124/mol.117.111401
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    Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains
    Onofrio Laselva, Steven Molinski, Valeria Casavola and Christine E. Bear
    Molecular Pharmacology June 2018, 93 (6) 612-618; DOI: https://doi.org/10.1124/mol.118.111799
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    Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms
    Andrew N. Keller, Irina Kufareva, Tracy M. Josephs, Jiayin Diao, Vyvyan T. Mai, Arthur D. Conigrave, Arthur Christopoulos, Karen J. Gregory and Katie Leach
    Molecular Pharmacology June 2018, 93 (6) 619-630; DOI: https://doi.org/10.1124/mol.118.112086
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    Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor
    Martina Stepankova, Iveta Bartonkova, Eva Jiskrova, Radim Vrzal, Sridhar Mani, Sandhya Kortagere and Zdenek Dvorak
    Molecular Pharmacology June 2018, 93 (6) 631-644; DOI: https://doi.org/10.1124/mol.118.112151
  • Open Access
    Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
    Sophie J. Bradley, Colin Molloy, Christoffer Bundgaard, Adrian J. Mogg, Karen J. Thompson, Louis Dwomoh, Helen E. Sanger, Michael D. Crabtree, Simon M. Brooke, Patrick M. Sexton, Christian C. Felder, Arthur Christopoulos, Lisa M. Broad, Andrew B. Tobin and Christopher J. Langmead
    Molecular Pharmacology June 2018, 93 (6) 645-656; DOI: https://doi.org/10.1124/mol.118.111872
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In this issue

Molecular Pharmacology: 93 (6)
Molecular Pharmacology
Vol. 93, Issue 6
1 Jun 2018
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  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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