Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)

Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan (T.M., N.K., Y.S., R.A., T.S.); Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan (M.I.-Y., S.M., H.K.); Institute for Quantitative Biosciences (H.Og.) and Department of Cellular and Molecular Pharmacology, Graduate School of Medicine (J.S., K.K., M.I.), The University of Tokyo, Tokyo, Japan; Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Tokyo, Japan (K.K., M.I.); and Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan (H.Oy., Y.K.)