Table of Contents

Articles

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  Inhibition of Class I Histone Deacetylases Abrogates Tumor Growth Factor β Expression and Development of Fibrosis during Chronic Pancreatitis

  Marta Bombardo, Rong Chen, Ermanno Malagola, Enrica Saponara, Andrew P. Hills, Rolf Graf and Sabrina Sonda

  Molecular Pharmacology August 2018, 94 (2) 793-801; DOI: https://doi.org/10.1124/mol.117.110924
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  Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation

  Zhibo Gai, Michele Visentin, Ting Gui, Lin Zhao, Wolfgang E. Thasler, Stephanie Häusler, Ivan Hartling, Alessio Cremonesi, Christian Hiller and Gerd A. Kullak-Ublick

  Molecular Pharmacology August 2018, 94 (2) 802-811; DOI: https://doi.org/10.1124/mol.117.111047
• Open Access

  Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer

  Philipp Y. Maximov, Balkees Abderrahman, Sean W. Fanning, Surojeet Sengupta, Ping Fan, Ramona F. Curpan, Daniela Maria Quintana Rincon, Jeffery A. Greenland, Shyamala S. Rajan, Geoffrey L. Greene and V. Craig Jordan

  Molecular Pharmacology August 2018, 94 (2) 812-822; DOI: https://doi.org/10.1124/mol.117.111385
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  Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition

  Cheng Chang, Kari R. Fonseca, Cheryl Li, Weldon Horner, Laura E. Zawadzke, Michelle A. Salafia, Kathryn A. Welch, Christine A. Strick, Brian M. Campbell, Steve S. Gernhardt, Haojing Rong, Aarti Sawant-Basak, Jennifer Liras, Amy Dounay, Jamison B. Tuttle, Patrick Verhoest and Tristan S. Maurer

  Molecular Pharmacology August 2018, 94 (2) 823-833; DOI: https://doi.org/10.1124/mol.118.111625
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  Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride–Induced Model of Liver Injury

  Todd R. Harris, Sean Kodani, Amy A. Rand, Jun Yang, Denise M. Imai, Sung Hee Hwang and Bruce D. Hammock

  Molecular Pharmacology August 2018, 94 (2) 834-841; DOI: https://doi.org/10.1124/mol.118.111831
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  Transmembrane Domain 1 of Human Organic Anion Transporting Polypeptide 2B1 Is Essential for Transporter Function and Stability

  Zihui Fang, Jiujiu Huang, Jie Chen, Shaopeng Xu, Zhaojian Xiang and Mei Hong

  Molecular Pharmacology August 2018, 94 (2) 842-849; DOI: https://doi.org/10.1124/mol.118.111914
• Open Access

  Small-Molecule Positive Allosteric Modulators of the β₂-Adrenoceptor Isolated from DNA-Encoded Libraries

  Seungkirl Ahn, Biswaranjan Pani, Alem W. Kahsai, Eva K. Olsen, Gitte Husemoen, Mikkel Vestergaard, Lei Jin, Shuai Zhao, Laura M. Wingler, Paula K. Rambarat, Rishabh K. Simhal, Thomas T. Xu, Lillian D. Sun, Paul J. Shim, Dean P. Staus, Li-Yin Huang, Thomas Franch, Xin Chen and Robert J. Lefkowitz

  Molecular Pharmacology August 2018, 94 (2) 850-861; DOI: https://doi.org/10.1124/mol.118.111948
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  Novel Paradigms Governing β₁-Adrenergic Receptor Trafficking in Primary Adult Rat Cardiac Myocytes

  Mohammed M. Nooh, Salvatore Mancarella and Suleiman W. Bahouth

  Molecular Pharmacology August 2018, 94 (2) 862-875; DOI: https://doi.org/10.1124/mol.118.112045
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  Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin–Treated Mice Demonstrates NRF2-Independent PKM2 Induction

  Rance Nault, Claire M. Doskey, Kelly A. Fader, Cheryl E. Rockwell and Tim Zacharewski

  Molecular Pharmacology August 2018, 94 (2) 876-884; DOI: https://doi.org/10.1124/mol.118.112144
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  Identification of WB4101, an α₁-Adrenoceptor Antagonist, as a Sodium Channel Blocker

  Min Li, Ying Wu, Beiyan Zou, Xiaoliang Wang, Min Li and Haibo Yu

  Molecular Pharmacology August 2018, 94 (2) 896-906; DOI: https://doi.org/10.1124/mol.117.111252
• Open Access

  Application of Mixture Design Response Surface Methodology for Combination Chemotherapy in PC-3 Human Prostate Cancer Cells

  Richard Oblad, Hayden Doughty, John Lawson, Merrill Christensen and Jason Kenealey

  Molecular Pharmacology August 2018, 94 (2) 907-916; DOI: https://doi.org/10.1124/mol.117.111450
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  Lipophilicity of the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing Effect on the Major CF-causing Mutation: F508del

  Stephanie Chin, Maurita Hung, Amy Won, Yu-Sheng Wu, Saumel Ahmadi, Donghe Yang, Salma Elmallah, Krimo Toutah, C. Michael Hamilton, Robert N. Young, Russell D. Viirre, Christopher M. Yip and Christine E. Bear

  Molecular Pharmacology August 2018, 94 (2) 917-925; DOI: https://doi.org/10.1124/mol.118.112177
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  Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

  Sujay V. Kharade, Haruto Kurata, Aaron M. Bender, Anna L. Blobaum, Eric E. Figueroa, Amanda Duran, Meghan Kramer, Emily Days, Paige Vinson, Daniel Flores, Lisa M. Satlin, Jens Meiler, C. David Weaver, Craig W. Lindsley, Corey R. Hopkins and Jerod S. Denton

  Molecular Pharmacology August 2018, 94 (2) 926-937; DOI: https://doi.org/10.1124/mol.118.112359