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Molecular Pharmacology

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Table of Contents

August 01, 2018; Volume 94,Issue 2

Minireview

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    Small-Molecule Inhibitors Targeting Protein SUMOylation as Novel Anticancer Compounds
    Yanfang Yang, Zijing Xia, Xixi Wang, Xinyu Zhao, Zenghua Sheng, Yang Ye, Gu He, Liangxue Zhou, Hongxia Zhu, Ningzhi Xu and Shufang Liang
    Molecular Pharmacology August 2018, 94 (2) 885-894; DOI: https://doi.org/10.1124/mol.118.112300

Articles

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    Inhibition of Class I Histone Deacetylases Abrogates Tumor Growth Factor β Expression and Development of Fibrosis during Chronic Pancreatitis
    Marta Bombardo, Rong Chen, Ermanno Malagola, Enrica Saponara, Andrew P. Hills, Rolf Graf and Sabrina Sonda
    Molecular Pharmacology August 2018, 94 (2) 793-801; DOI: https://doi.org/10.1124/mol.117.110924
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    Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation
    Zhibo Gai, Michele Visentin, Ting Gui, Lin Zhao, Wolfgang E. Thasler, Stephanie Häusler, Ivan Hartling, Alessio Cremonesi, Christian Hiller and Gerd A. Kullak-Ublick
    Molecular Pharmacology August 2018, 94 (2) 802-811; DOI: https://doi.org/10.1124/mol.117.111047
  • Open Access
    Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer
    Philipp Y. Maximov, Balkees Abderrahman, Sean W. Fanning, Surojeet Sengupta, Ping Fan, Ramona F. Curpan, Daniela Maria Quintana Rincon, Jeffery A. Greenland, Shyamala S. Rajan, Geoffrey L. Greene and V. Craig Jordan
    Molecular Pharmacology August 2018, 94 (2) 812-822; DOI: https://doi.org/10.1124/mol.117.111385
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    Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition
    Cheng Chang, Kari R. Fonseca, Cheryl Li, Weldon Horner, Laura E. Zawadzke, Michelle A. Salafia, Kathryn A. Welch, Christine A. Strick, Brian M. Campbell, Steve S. Gernhardt, Haojing Rong, Aarti Sawant-Basak, Jennifer Liras, Amy Dounay, Jamison B. Tuttle, Patrick Verhoest and Tristan S. Maurer
    Molecular Pharmacology August 2018, 94 (2) 823-833; DOI: https://doi.org/10.1124/mol.118.111625
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    Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride–Induced Model of Liver Injury
    Todd R. Harris, Sean Kodani, Amy A. Rand, Jun Yang, Denise M. Imai, Sung Hee Hwang and Bruce D. Hammock
    Molecular Pharmacology August 2018, 94 (2) 834-841; DOI: https://doi.org/10.1124/mol.118.111831
  • Transmembrane Domain 1 of Human Organic Anion Transporting Polypeptide 2B1 Is Essential for Transporter Function and Stability
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    Transmembrane Domain 1 of Human Organic Anion Transporting Polypeptide 2B1 Is Essential for Transporter Function and Stability
    Zihui Fang, Jiujiu Huang, Jie Chen, Shaopeng Xu, Zhaojian Xiang and Mei Hong
    Molecular Pharmacology August 2018, 94 (2) 842-849; DOI: https://doi.org/10.1124/mol.118.111914
  • Open Access
    Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries
    Seungkirl Ahn, Biswaranjan Pani, Alem W. Kahsai, Eva K. Olsen, Gitte Husemoen, Mikkel Vestergaard, Lei Jin, Shuai Zhao, Laura M. Wingler, Paula K. Rambarat, Rishabh K. Simhal, Thomas T. Xu, Lillian D. Sun, Paul J. Shim, Dean P. Staus, Li-Yin Huang, Thomas Franch, Xin Chen and Robert J. Lefkowitz
    Molecular Pharmacology August 2018, 94 (2) 850-861; DOI: https://doi.org/10.1124/mol.118.111948
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    Novel Paradigms Governing β1-Adrenergic Receptor Trafficking in Primary Adult Rat Cardiac Myocytes
    Mohammed M. Nooh, Salvatore Mancarella and Suleiman W. Bahouth
    Molecular Pharmacology August 2018, 94 (2) 862-875; DOI: https://doi.org/10.1124/mol.118.112045
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    Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin–Treated Mice Demonstrates NRF2-Independent PKM2 Induction
    Rance Nault, Claire M. Doskey, Kelly A. Fader, Cheryl E. Rockwell and Tim Zacharewski
    Molecular Pharmacology August 2018, 94 (2) 876-884; DOI: https://doi.org/10.1124/mol.118.112144
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    Identification of WB4101, an α1-Adrenoceptor Antagonist, as a Sodium Channel Blocker
    Min Li, Ying Wu, Beiyan Zou, Xiaoliang Wang, Min Li and Haibo Yu
    Molecular Pharmacology August 2018, 94 (2) 896-906; DOI: https://doi.org/10.1124/mol.117.111252
  • Open Access
    Application of Mixture Design Response Surface Methodology for Combination Chemotherapy in PC-3 Human Prostate Cancer Cells
    Richard Oblad, Hayden Doughty, John Lawson, Merrill Christensen and Jason Kenealey
    Molecular Pharmacology August 2018, 94 (2) 907-916; DOI: https://doi.org/10.1124/mol.117.111450
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    Lipophilicity of the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing Effect on the Major CF-causing Mutation: F508del
    Stephanie Chin, Maurita Hung, Amy Won, Yu-Sheng Wu, Saumel Ahmadi, Donghe Yang, Salma Elmallah, Krimo Toutah, C. Michael Hamilton, Robert N. Young, Russell D. Viirre, Christopher M. Yip and Christine E. Bear
    Molecular Pharmacology August 2018, 94 (2) 917-925; DOI: https://doi.org/10.1124/mol.118.112177
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    Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992
    Sujay V. Kharade, Haruto Kurata, Aaron M. Bender, Anna L. Blobaum, Eric E. Figueroa, Amanda Duran, Meghan Kramer, Emily Days, Paige Vinson, Daniel Flores, Lisa M. Satlin, Jens Meiler, C. David Weaver, Craig W. Lindsley, Corey R. Hopkins and Jerod S. Denton
    Molecular Pharmacology August 2018, 94 (2) 926-937; DOI: https://doi.org/10.1124/mol.118.112359

Erratum

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    Correction to “Agonist-Dependent and-Independent κ Opioid Receptor Phosphorylation: Distinct Phosphorylation Patterns and Different Cellular Outcomes”
    Molecular Pharmacology August 2018, 94 (2) 895; DOI: https://doi.org/10.1124/mol.117.108555err
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Molecular Pharmacology: 94 (2)
Molecular Pharmacology
Vol. 94, Issue 2
1 Aug 2018
  • Table of Contents
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  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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