Fig. 3. Response surfaces of 12 different mixtures. Bright red areas represent the most effective combinations at reducing cell viability. Deep red, gray, and blue are listed in descending order of effectiveness. The numbers within each contour represent the maximum prediction found within that contour, meaning that all predictions within that contour are less than or equal to the number found within but greater than the numbers found in the lower contours. The maximum point on the surface is indicated by a diamond. The mixtures for each ternary plot are: (A) DOC, CAB, PIP; (B) DOC, CAB, FLAV; (C) FLAV, MIT, CAB; (D) FLAV, PIP, CAB; (E) FLAV, PIP, MIT; (F) PIP, MIT, CAB; (G) RES, FLAV, CAB; (H) RES, FLAV, MIT; (I) RES, FLAV, PIP; (J) RES, MIT, CAB; (K) RES, PIP, CAB; (L) RES, PIP, MIT. All data were obtained by Alamarblue cell viability assay with three biologic replicates in triplicate.