Table of Contents

Articles

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  Intergenic Splicing between Four Adjacent UGT Genes (2B15, 2B29P2, 2B17, 2B29P1) Gives Rise to Variant UGT Proteins That Inhibit Glucuronidation via Protein-Protein Interactions

  Dong Gui Hu, Julie-Ann Hulin, Dhilushi D. Wijayakumara, Ross A. McKinnon, Peter I. Mackenzie and Robyn Meech

  Molecular Pharmacology September 2018, 94 (3) 938-952; DOI: https://doi.org/10.1124/mol.118.111773
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  Nucleosome Positioning and Gene Regulation of the SGLT2 Gene in the Renal Proximal Tubular Epithelial Cells

  Hiroaki Takesue, Takeshi Hirota, Mami Tachimura, Ayane Tokashiki and Ichiro Ieiri

  Molecular Pharmacology September 2018, 94 (3) 953-962; DOI: https://doi.org/10.1124/mol.118.111807
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  A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling

  Monica Soto-Velasquez, Michael P. Hayes, Aktan Alpsoy, Emily C. Dykhuizen and Val J. Watts

  Molecular Pharmacology September 2018, 94 (3) 963-972; DOI: https://doi.org/10.1124/mol.118.111849
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  Molecular Determinants of the Differential Modulation of Ca_v1.2 and Ca_v1.3 by Nifedipine and FPL 64176

  Yuchen Wang, Shiqi Tang, Kyle E. Harvey, Amy E. Salyer, T. August Li, Emily K. Rantz, Markus A. Lill and Gregory H. Hockerman

  Molecular Pharmacology September 2018, 94 (3) 973-983; DOI: https://doi.org/10.1124/mol.118.112441
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  Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery

  Yoshihiro Morishima, Ranjit K. Mehta, Miyako Yoshimura, Miranda Lau, Daniel R. Southworth, Theodore S. Lawrence, William B. Pratt, Mukesh K. Nyati and Yoichi Osawa

  Molecular Pharmacology September 2018, 94 (3) 984-991; DOI: https://doi.org/10.1124/mol.118.112516
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  Equilibrium Assays Are Required to Accurately Characterize the Activity Profiles of Drugs Modulating Gq-Protein-Coupled Receptors

  Sara Bdioui, Julien Verdi, Nicolas Pierre, Eric Trinquet, Thomas Roux and Terry Kenakin

  Molecular Pharmacology September 2018, 94 (3) 992-1006; DOI: https://doi.org/10.1124/mol.118.112573
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  Long-Acting β₂-Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)–Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR

  Christopher F. Rider, Mohammed O. Altonsy, Mahmoud M. Mostafa, Suharsh V. Shah, Sarah Sasse, Martijn L. Manson, Dong Yan, Carina Kärrman-Mårdh, Anna Miller-Larsson, Anthony N. Gerber, Mark A. Giembycz and Robert Newton

  Molecular Pharmacology September 2018, 94 (3) 1031-1046; DOI: https://doi.org/10.1124/mol.118.112755
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  Voltage-Gated Sodium Channels Regulating Action Potential Generation in Itch-, Nociceptive-, and Low-Threshold Mechanosensitive Cutaneous C-Fibers

  Danica Jurcakova, Fei Ru, Marian Kollarik, Hui Sun, Jeffrey Krajewski and Bradley J. Undem

  Molecular Pharmacology September 2018, 94 (3) 1047-1056; DOI: https://doi.org/10.1124/mol.118.112839
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  Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates

  Philip J. Sandoval, Kimberley M. Zorn, Alex M. Clark, Sean Ekins and Stephen H. Wright

  Molecular Pharmacology September 2018, 94 (3) 1057-1068; DOI: https://doi.org/10.1124/mol.117.111443
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  An Outward-Facing Aromatic Amino Acid Is Crucial for Signaling between the Membrane-Spanning and Nucleotide-Binding Domains of Multidrug Resistance Protein 1 (MRP1; ABCC1)

  Kevin E. Weigl, Gwenaëlle Conseil, Alice J. Rothnie, May Arama, Yossi Tsfadia and Susan P. C. Cole

  Molecular Pharmacology September 2018, 94 (3) 1069-1078; DOI: https://doi.org/10.1124/mol.118.112615
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  Small-Molecule G Protein–Coupled Receptor Kinase Inhibitors Attenuate G Protein–Coupled Receptor Kinase 2–Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions

  Richard D. Rainbow, Sean Brennan, Robert Jackson, Alison J. Beech, Amal Bengreed, Helen V. Waldschmidt, John J. G. Tesmer, R. A. John Challiss and Jonathon M. Willets

  Molecular Pharmacology September 2018, 94 (3) 1079-1091; DOI: https://doi.org/10.1124/mol.118.112524
• Open Access

  The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels

  Grace Woodruff, Christian G. Bouwkamp, Femke M. de Vrij, Timothy Lovenberg, Pascal Bonaventure, Steven A. Kushner and Anthony W. Harrington

  Molecular Pharmacology September 2018, 94 (3) 1092-1100; DOI: https://doi.org/10.1124/mol.118.112557