Molecular Pharmacology: 94 (4)

October 01, 2018; Volume 94,Issue 4

Articles

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RGS10 Regulates the Expression of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha through a G Protein–Independent Mechanism
Mohammed Alqinyah, Faris Almutairi, Menbere Y. Wendimu and Shelley B. Hooks

Molecular Pharmacology October 2018, 94 (4) 1103-1113; DOI: https://doi.org/10.1124/mol.118.111674
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The Conorfamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand–Sensing Domain
Melissa Reiners, Michael A. Margreiter, Adrienne Oslender-Bujotzek, Giulia Rossetti, Stefan Gründer and Axel Schmidt

Molecular Pharmacology October 2018, 94 (4) 1114-1124; DOI: https://doi.org/10.1124/mol.118.112375
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Organic Cation Transporter 3 Facilitates Fetal Exposure to Metformin during Pregnancy
Nora Lee, Mary F. Hebert, David J. Wagner, Thomas R. Easterling, C. Jason Liang, Kenneth Rice and Joanne Wang

Molecular Pharmacology October 2018, 94 (4) 1125-1131; DOI: https://doi.org/10.1124/mol.118.112482
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Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration
Songqi Gao, Tanu Parmar, Grazyna Palczewska, Zhiqian Dong, Marcin Golczak, Krzysztof Palczewski and Beata Jastrzebska

Molecular Pharmacology October 2018, 94 (4) 1132-1144; DOI: https://doi.org/10.1124/mol.118.112581
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Chronic Activation of Liver X Receptor Sensitizes Mice to High Cholesterol Diet–Induced Gut Toxicity
Wojciech G. Garbacz, Hirdesh Uppal, Jiong Yan, Meishu Xu, Songrong Ren, Donna B. Stolz, Min Huang and Wen Xie

Molecular Pharmacology October 2018, 94 (4) 1145-1154; DOI: https://doi.org/10.1124/mol.118.112672
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Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels
Rían W. Manville and Geoffrey W. Abbott

Molecular Pharmacology October 2018, 94 (4) 1155-1163; DOI: https://doi.org/10.1124/mol.118.112953
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Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin
Xiao-Ying Sun, Li-Lan Sun, Hang Qi, Qin Gao, Gong-Xin Wang, Ning-Ning Wei and KeWei Wang

Molecular Pharmacology October 2018, 94 (4) 1164-1173; DOI: https://doi.org/10.1124/mol.118.112466
Open Access
Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB–Dependent Inflammatory Signaling in Astrocytes
Katriana A. Popichak, Sean L. Hammond, Julie A. Moreno, Maryam F. Afzali, Donald S. Backos, Richard D. Slayden, Stephen Safe and Ronald B. Tjalkens

Molecular Pharmacology October 2018, 94 (4) 1174-1186; DOI: https://doi.org/10.1124/mol.118.112631
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Bortezomib Targets Sp Transcription Factors in Cancer Cells
Keshav Karki, Sneha Harishchandra and Stephen Safe

Molecular Pharmacology October 2018, 94 (4) 1187-1196; DOI: https://doi.org/10.1124/mol.118.112797
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Identification of Positive Allosteric Modulators of the D₁ Dopamine Receptor That Act at Diverse Binding Sites
Kathryn D. Luderman, Jennie L. Conroy, R. Benjamin Free, Noel Southall, Marc Ferrer, Marta Sanchez-Soto, Amy E. Moritz, Blair K. A. Willette, Tim J. Fyfe, Prashi Jain, Steve Titus, Lisa A. Hazelwood, Jeffrey Aubé, J. Robert Lane, Kevin J. Frankowski and David R. Sibley

Molecular Pharmacology October 2018, 94 (4) 1197-1209; DOI: https://doi.org/10.1124/mol.118.113175
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Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition
Tyler S. Beyett, Xinmin Gan, Shannon M. Reilly, Louise Chang, Andrew V. Gomez, Alan R. Saltiel, Hollis D. Showalter and John J. G. Tesmer

Molecular Pharmacology October 2018, 94 (4) 1210-1219; DOI: https://doi.org/10.1124/mol.118.112185
Open Access
Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro
Diana Lupu, Mukesh K. Varshney, Daniel Mucs, José Inzunza, Ulf Norinder, Felicia Loghin, Ivan Nalvarte and Joëlle Rüegg

Molecular Pharmacology October 2018, 94 (4) 1220-1231; DOI: https://doi.org/10.1124/mol.118.112342
Open Access
Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor
Xushan Wang, Beverly A. Heinz, Yue-Wei Qian, Joan H. Carter, Robert A. Gadski, Lisa S. Beavers, Sheila P. Little, Charles R. Yang, James P. Beck, Junliang Hao, John M. Schaus, Kjell A. Svensson and Robert F. Bruns

Molecular Pharmacology October 2018, 94 (4) 1232-1245; DOI: https://doi.org/10.1124/mol.118.112649