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Molecular Pharmacology

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Research ArticleArticle

Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin–Dependent Responses

Caitlin A. D. Jagla, Caitlin E. Scott, Yaliang Tang, Changjiang Qiao, Gabriel E. Mateo-Semidey, Guillermo A. Yudowski, Dai Lu and Debra A. Kendall
Molecular Pharmacology January 2019, 95 (1) 1-10; DOI: https://doi.org/10.1124/mol.118.112854
Caitlin A. D. Jagla
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (C.A.D.J., C.E.S., Y.T., D.A.K.); Department of Anatomy and Neurobiology (G.E.M.-S., G.A.Y.) and Institute of Neurobiology (G.E.M.-S., G.A.Y.), University of Puerto Rico, San Juan, Puerto Rico; and Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas (C.Q., D.L.)
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Caitlin E. Scott
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (C.A.D.J., C.E.S., Y.T., D.A.K.); Department of Anatomy and Neurobiology (G.E.M.-S., G.A.Y.) and Institute of Neurobiology (G.E.M.-S., G.A.Y.), University of Puerto Rico, San Juan, Puerto Rico; and Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas (C.Q., D.L.)
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Yaliang Tang
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (C.A.D.J., C.E.S., Y.T., D.A.K.); Department of Anatomy and Neurobiology (G.E.M.-S., G.A.Y.) and Institute of Neurobiology (G.E.M.-S., G.A.Y.), University of Puerto Rico, San Juan, Puerto Rico; and Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas (C.Q., D.L.)
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Changjiang Qiao
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (C.A.D.J., C.E.S., Y.T., D.A.K.); Department of Anatomy and Neurobiology (G.E.M.-S., G.A.Y.) and Institute of Neurobiology (G.E.M.-S., G.A.Y.), University of Puerto Rico, San Juan, Puerto Rico; and Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas (C.Q., D.L.)
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Gabriel E. Mateo-Semidey
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (C.A.D.J., C.E.S., Y.T., D.A.K.); Department of Anatomy and Neurobiology (G.E.M.-S., G.A.Y.) and Institute of Neurobiology (G.E.M.-S., G.A.Y.), University of Puerto Rico, San Juan, Puerto Rico; and Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas (C.Q., D.L.)
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Guillermo A. Yudowski
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (C.A.D.J., C.E.S., Y.T., D.A.K.); Department of Anatomy and Neurobiology (G.E.M.-S., G.A.Y.) and Institute of Neurobiology (G.E.M.-S., G.A.Y.), University of Puerto Rico, San Juan, Puerto Rico; and Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas (C.Q., D.L.)
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Dai Lu
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (C.A.D.J., C.E.S., Y.T., D.A.K.); Department of Anatomy and Neurobiology (G.E.M.-S., G.A.Y.) and Institute of Neurobiology (G.E.M.-S., G.A.Y.), University of Puerto Rico, San Juan, Puerto Rico; and Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas (C.Q., D.L.)
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Debra A. Kendall
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (C.A.D.J., C.E.S., Y.T., D.A.K.); Department of Anatomy and Neurobiology (G.E.M.-S., G.A.Y.) and Institute of Neurobiology (G.E.M.-S., G.A.Y.), University of Puerto Rico, San Juan, Puerto Rico; and Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas (C.Q., D.L.)
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Article Information

vol. 95 no. 1 1-10
DOI 
https://doi.org/10.1124/mol.118.112854
PubMed 
30322873

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 27, 2018
  • Accepted October 12, 2018
  • Published online November 30, 2018.

Article Versions

  • Earlier version (October 15, 2018 - 05:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Caitlin A. D. Jagla,
  2. Caitlin E. Scott,
  3. Yaliang Tang,
  4. Changjiang Qiao,
  5. Gabriel E. Mateo-Semidey,
  6. Guillermo A. Yudowski,
  7. Dai Lu, and
  8. Debra A. Kendall
  1. Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (C.A.D.J., C.E.S., Y.T., D.A.K.); Department of Anatomy and Neurobiology (G.E.M.-S., G.A.Y.) and Institute of Neurobiology (G.E.M.-S., G.A.Y.), University of Puerto Rico, San Juan, Puerto Rico; and Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas (C.Q., D.L.)
  1. Address correspondence to:
    Debra A. Kendall, Department of Pharmaceutical Sciences, University of Connecticut, 69 N. Eagleville Road, Storrs, CT 06269-3092. E-mail: debra.kendall{at}uconn.edu
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Molecular Pharmacology: 95 (1)
Molecular Pharmacology
Vol. 95, Issue 1
1 Jan 2019
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Research ArticleArticle

Pyrimidinyl Biphenylureas as Allosteric Modulators of CB1

Caitlin A. D. Jagla, Caitlin E. Scott, Yaliang Tang, Changjiang Qiao, Gabriel E. Mateo-Semidey, Guillermo A. Yudowski, Dai Lu and Debra A. Kendall
Molecular Pharmacology January 1, 2019, 95 (1) 1-10; DOI: https://doi.org/10.1124/mol.118.112854

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Research ArticleArticle

Pyrimidinyl Biphenylureas as Allosteric Modulators of CB1

Caitlin A. D. Jagla, Caitlin E. Scott, Yaliang Tang, Changjiang Qiao, Gabriel E. Mateo-Semidey, Guillermo A. Yudowski, Dai Lu and Debra A. Kendall
Molecular Pharmacology January 1, 2019, 95 (1) 1-10; DOI: https://doi.org/10.1124/mol.118.112854
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