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Molecular Pharmacology

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Table of Contents

March 01, 2019; Volume 95,Issue 3

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    Functional Selectivity and Partial Efficacy at the Monoamine Transporters: A Unified Model of Allosteric Modulation and Amphetamine-Induced Substrate Release
    Peter S. Hasenhuetl, Shreyas Bhat, Michael Freissmuth and Walter Sandtner
    Molecular Pharmacology March 2019, 95 (3) 303-312; DOI: https://doi.org/10.1124/mol.118.114793

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    Mexiletine Block of Voltage-Gated Sodium Channels: Isoform- and State-Dependent Drug–Pore Interactions
    Hiroki Nakagawa, Tatsuo Munakata and Akihiko Sunami
    Molecular Pharmacology March 2019, 95 (3) 236-244; DOI: https://doi.org/10.1124/mol.118.114025
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    Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor
    Aditya J. Desai, Ingrid Mechin, Karthigeyan Nagarajan, Celine Valant, Denise Wootten, Polo C. H. Lam, Andrew Orry, Ruben Abagyan, Anil Nair, Patrick M. Sexton, Arthur Christopoulos and Laurence J. Miller
    Molecular Pharmacology March 2019, 95 (3) 245-259; DOI: https://doi.org/10.1124/mol.118.114082
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    Repeated Exposure to 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an Active Metabolite of Bisphenol A, Aggressively Stimulates Breast Cancer Cell Growth in an Estrogen Receptor β (ERβ)–Dependent Manner
    Masayo Hirao-Suzuki, Shuso Takeda, Katsuhiro Okuda, Masufumi Takiguchi and Shin’ichi Yoshihara
    Molecular Pharmacology March 2019, 95 (3) 260-268; DOI: https://doi.org/10.1124/mol.118.114124
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    S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization
    Jean A. Boutin, Frederic Bouillaud, Elzbieta Janda, István Gacsalyi, Gérald Guillaumet, Etienne C. Hirsch, Daniel A. Kane, Françoise Nepveu, Karine Reybier, Philippe Dupuis, Marc Bertrand, Monivan Chhour, Thierry Le Diguarher, Mathias Antoine, Karen Brebner, Hervé Da Costa, Pierre Ducrot, Adeline Giganti, Vishalgiri Goswami, Hala Guedouari, Patrick P. Michel, Aakash Patel, Jérôme Paysant, Johann Stojko, Marie-Claude Viaud-Massuard and Gilles Ferry
    Molecular Pharmacology March 2019, 95 (3) 269-285; DOI: https://doi.org/10.1124/mol.118.114231
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    Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083
    Wai Kwan Tang, Taivan Odzorig, Whitney Jin and Di Xia
    Molecular Pharmacology March 2019, 95 (3) 286-293; DOI: https://doi.org/10.1124/mol.118.114256
  • Inhibition of Interleukin 10 Transcription through the SMAD2/3 Signaling Pathway by Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel K<sub>Ca</sub>3.1 Activation in Human T-Cell Lymphoma HuT-78 Cells
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    Inhibition of Interleukin 10 Transcription through the SMAD2/3 Signaling Pathway by Ca2+-Activated K+ Channel KCa3.1 Activation in Human T-Cell Lymphoma HuT-78 Cells
    Miki Matsui, Junko Kajikuri, Hiroaki Kito, Kyoko Endo, Yuki Hasegawa, Shinya Murate and Susumu Ohya
    Molecular Pharmacology March 2019, 95 (3) 294-302; DOI: https://doi.org/10.1124/mol.118.114405
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    Hyperforin-Induced Activation of the Pregnane X Receptor Is Influenced by the Organic Anion-Transporting Polypeptide 2B1
    Anima M. Schäfer, Olivier Potterat, Isabell Seibert, Orlando Fertig and Henriette E. Meyer zu Schwabedissen
    Molecular Pharmacology March 2019, 95 (3) 313-323; DOI: https://doi.org/10.1124/mol.118.114066
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    Belinostat, at Its Clinically Relevant Concentrations, Inhibits Rifampicin-Induced CYP3A4 and MDR1 Gene Expression
    Kodye L. Abbott, Chloe S. Chaudhury, Aneesh Chandran, Saraswathi Vishveshwara, Zdenek Dvorak, Eva Jiskrova, Karolina Poulikova, Barbora Vyhlidalova, Sridhar Mani and Satyanarayana R. Pondugula
    Molecular Pharmacology March 2019, 95 (3) 324-334; DOI: https://doi.org/10.1124/mol.118.114587
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In this issue

Molecular Pharmacology: 95 (3)
Molecular Pharmacology
Vol. 95, Issue 3
1 Mar 2019
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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