Article Figures & Data
Figures
Tables
Data Supplement
- Supplemental Data -
Supplemental Methods
Supplemental Table 1 - Comparison of residues that interact with compound 3 and Taxol in human P-gp (pdb.6QEX).
Supplemental Table 2 - List of residues interacting with compound 8 and Taxol in human P-gp 6QEX structure.
Supplemental Figure 1 - Effect of compounds 9 (A), 10 (B) and 11 (C) on the ATPase activity of P-gp.
Supplemental Figure 2 - Effect of compounds 15 (A) and 18 (B) on the ATPase activity of P-gp.
Supplemental Figure 3 - Effect of compounds 22 (A) and 23 (B) on the ATPase activity of P-gp.
Supplemental Figure 4 - The effect of compounds 24 on the ATPase activity of P-gp (A), and the photoaffinity labeling of P-gp by [125I]-iodoarylazidoprazosin (IAAP) (B).
Supplemental Figure 5 - Bodipy conjugated compound 24 is not transported by Pgp.
Supplemental Figure 6 - The cluster of 20 docking poses of Compounds 3 (A) and 8 (B) in the drug-binding pocket of human P-gp structure (pdb: 6QEX) generated by the AutoDock Vina program.
- Supplemental Data -