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Research ArticleArticle

Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain

Patrick Marcinkowski, Annika Kreuchwig, Sandro Mendieta, Inna Hoyer, Franziska Witte, Jens Furkert, Claudia Rutz, Dieter Lentz, Gerd Krause and Ralf Schülein
Molecular Pharmacology October 2019, 96 (4) 452-462; DOI: https://doi.org/10.1124/mol.119.116947
Patrick Marcinkowski
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Annika Kreuchwig
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Sandro Mendieta
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Inna Hoyer
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Franziska Witte
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Jens Furkert
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Claudia Rutz
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Dieter Lentz
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Gerd Krause
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Ralf Schülein
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
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Article Information

vol. 96 no. 4 452-462
DOI 
https://doi.org/10.1124/mol.119.116947
PubMed 
31399504

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 29, 2019
  • Accepted July 23, 2019
  • Published online September 10, 2019.

Article Versions

  • Earlier version (August 9, 2019 - 18:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Patrick Marcinkowski,
  2. Annika Kreuchwig,
  3. Sandro Mendieta,
  4. Inna Hoyer,
  5. Franziska Witte1,
  6. Jens Furkert,
  7. Claudia Rutz,
  8. Dieter Lentz,
  9. Gerd Krause, and
  10. Ralf Schülein
  1. Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)
  1. Address correspondence to:
    Dr. Gerd Krause, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany. E-mail: GKrause{at}fmp-berlin.de
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Molecular Pharmacology: 96 (4)
Molecular Pharmacology
Vol. 96, Issue 4
1 Oct 2019
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Research ArticleArticle

TSHR Intramolecular Mechanisms Illuminated by PAM and NAM

Patrick Marcinkowski, Annika Kreuchwig, Sandro Mendieta, Inna Hoyer, Franziska Witte, Jens Furkert, Claudia Rutz, Dieter Lentz, Gerd Krause and Ralf Schülein
Molecular Pharmacology October 1, 2019, 96 (4) 452-462; DOI: https://doi.org/10.1124/mol.119.116947

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Research ArticleArticle

TSHR Intramolecular Mechanisms Illuminated by PAM and NAM

Patrick Marcinkowski, Annika Kreuchwig, Sandro Mendieta, Inna Hoyer, Franziska Witte, Jens Furkert, Claudia Rutz, Dieter Lentz, Gerd Krause and Ralf Schülein
Molecular Pharmacology October 1, 2019, 96 (4) 452-462; DOI: https://doi.org/10.1124/mol.119.116947
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