Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain

Patrick Marcinkowski; Annika Kreuchwig; Sandro Mendieta; Inna Hoyer; Franziska Witte; Jens Furkert; Claudia Rutz; Dieter Lentz; Gerd Krause; Ralf Schülein

doi:10.1124/mol.119.116947

Research ArticleArticle

Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain

Patrick Marcinkowski, Annika Kreuchwig, Sandro Mendieta, Inna Hoyer, Franziska Witte, Jens Furkert, Claudia Rutz, Dieter Lentz, Gerd Krause and Ralf Schülein

Molecular Pharmacology October 2019, 96 (4) 452-462; DOI: https://doi.org/10.1124/mol.119.116947

Patrick Marcinkowski

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)

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Annika Kreuchwig

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Sandro Mendieta

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Inna Hoyer

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Franziska Witte

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Jens Furkert

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Claudia Rutz

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Dieter Lentz

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Gerd Krause

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Ralf Schülein

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Article Information

vol. 96 no. 4 452-462

DOI

https://doi.org/10.1124/mol.119.116947

PubMed

31399504

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0026-895X

Online ISSN

1521-0111

History

Received April 29, 2019
Accepted July 23, 2019
Published online September 10, 2019.

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Earlier version (August 9, 2019 - 18:11).
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Author Information

Patrick Marcinkowski,
Annika Kreuchwig,
Sandro Mendieta,
Inna Hoyer,
Franziska Witte¹,
Jens Furkert,
Claudia Rutz,
Dieter Lentz,
Gerd Krause, and
Ralf Schülein

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany (P.M., A.K., S.M., I.H., F.W., J.F., C.R., G.K., R.S.) and Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Berlin, Germany (D.L.)

Address correspondence to:
Dr. Gerd Krause, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany. E-mail: GKrause{at}fmp-berlin.de

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Research ArticleArticle

TSHR Intramolecular Mechanisms Illuminated by PAM and NAM

Patrick Marcinkowski, Annika Kreuchwig, Sandro Mendieta, Inna Hoyer, Franziska Witte, Jens Furkert, Claudia Rutz, Dieter Lentz, Gerd Krause and Ralf Schülein

Molecular Pharmacology October 1, 2019, 96 (4) 452-462; DOI: https://doi.org/10.1124/mol.119.116947

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Research ArticleArticle

TSHR Intramolecular Mechanisms Illuminated by PAM and NAM

Patrick Marcinkowski, Annika Kreuchwig, Sandro Mendieta, Inna Hoyer, Franziska Witte, Jens Furkert, Claudia Rutz, Dieter Lentz, Gerd Krause and Ralf Schülein

Molecular Pharmacology October 1, 2019, 96 (4) 452-462; DOI: https://doi.org/10.1124/mol.119.116947

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