Molecular Pharmacology: 96 (5)

November 01, 2019; Volume 96,Issue 5

Special Section on Computational Analysis of GPCRs

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Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?
Christopher T. Szlenk, Jeevan B. GC and Senthil Natesan

Molecular Pharmacology November 2019, 96 (5) 527-541; DOI: https://doi.org/10.1124/mol.118.115113
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A Biased View of μ-Opioid Receptors?
Alexandra E. Conibear and Eamonn Kelly

Molecular Pharmacology November 2019, 96 (5) 542-549; DOI: https://doi.org/10.1124/mol.119.115956
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Understanding Peptide Binding in Class A G Protein-Coupled Receptors
Irina G. Tikhonova, Veronique Gigoux and Daniel Fourmy

Molecular Pharmacology November 2019, 96 (5) 550-561; DOI: https://doi.org/10.1124/mol.119.115915

Articles

Open Access
The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
Ian G. Cowell, Elise M. Ling, Rebecca L. Swan, Matilda L.W. Brooks and Caroline A. Austin

Molecular Pharmacology November 2019, 96 (5) 562-572; DOI: https://doi.org/10.1124/mol.119.117390
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Arylamine N-Acetyltransferase 1 Regulates Expression of Matrix Metalloproteinase 9 in Breast Cancer Cells: Role of Hypoxia-Inducible Factor 1-α
Pengcheng Li, Neville J. Butcher and Rodney F. Minchin

Molecular Pharmacology November 2019, 96 (5) 573-579; DOI: https://doi.org/10.1124/mol.119.117432
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Metal Coordination Is Crucial for Geranylgeranyl Diphosphate Synthase–Bisphosphonate Interactions: A Crystallographic and Computational Analysis
Michal Lisnyansky, Elon Yariv, Omri Segal, Milit Marom, Anat Loewenstein, Nir Ben-Tal, Moshe Giladi and Yoni Haitin

Molecular Pharmacology November 2019, 96 (5) 580-588; DOI: https://doi.org/10.1124/mol.119.117499
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Isoliquiritigenin, an Orally Available Natural FLT3 Inhibitor from Licorice, Exhibits Selective Anti–Acute Myeloid Leukemia Efficacy In Vitro and In Vivo
Zhi-Xing Cao, Yi Wen, Jun-Lin He, Shen-Zhen Huang, Fei Gao, Chuan-Jie Guo, Qing-Qing Liu, Shu-Wen Zheng, Dao-Yin Gong, Yu-Zhi Li, Ruo-Qi Zhang, Jian-Ping Chen and Cheng Peng

Molecular Pharmacology November 2019, 96 (5) 589-599; DOI: https://doi.org/10.1124/mol.119.116129
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CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis
Kaoru Kobayashi, Jiro Kuze, Satoshi Abe, Shoko Takehara, Genki Minegishi, Katsuhide Igarashi, Satoshi Kitajima, Jun Kanno, Takushi Yamamoto, Mitsuo Oshimura and Yasuhiro Kazuki

Molecular Pharmacology November 2019, 96 (5) 600-608; DOI: https://doi.org/10.1124/mol.119.117333
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Selective Inhibition of Spindle Microtubules by a Tubulin-Binding Quinazoline Derivative
Jun-ichi Sawada, Hirosuke Ishii, Kenji Matsuno, Masayuki Sato, Yumiko Suzuki and Akira Asai

Molecular Pharmacology November 2019, 96 (5) 609-618; DOI: https://doi.org/10.1124/mol.119.116624
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Probing the CB₁ Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist
Robert B. Laprairie, Kiran Vemuri, Edward L. Stahl, Anisha Korde, Jo-Hao Ho, Travis W. Grim, Tian Hua, Yiran Wu, Raymond C. Stevens, Zhi-Jie Liu, Alexandros Makriyannis and Laura M. Bohn

Molecular Pharmacology November 2019, 96 (5) 619-628; DOI: https://doi.org/10.1124/mol.119.116483
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A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein
Tobie D. Lee, Olivia W. Lee, Kyle R. Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G. Tebase, Carleen Klumpp-Thomas, Robert W. Robey, Suresh V. Ambudkar, Min Shen, Michael M. Gottesman and Matthew D. Hall

Molecular Pharmacology November 2019, 96 (5) 629-640; DOI: https://doi.org/10.1124/mol.119.115964
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Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-Ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance
Doyoung Kwon, Sung-Mi Kim, Peyton Jacob, Yi Liu and Maria Almira Correia

Molecular Pharmacology November 2019, 96 (5) 641-654; DOI: https://doi.org/10.1124/mol.119.117069
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The Basis for Strain-Dependent Rat Aldehyde Dehydrogenase 1A7 (ALDH1A7) Gene Expression
Katerina Touloupi, Jenni Küblbeck, Angeliki Magklara, Ferdinand Molnár, Mika Reinisalo, Maria Konstandi, Paavo Honkakoski and Periklis Pappas

Molecular Pharmacology November 2019, 96 (5) 655-663; DOI: https://doi.org/10.1124/mol.119.117424
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Oligoarginine Peptides, a New Family of Nicotinic Acetylcholine Receptor Inhibitors
Dmitry S. Lebedev, Elena V. Kryukova, Igor A. Ivanov, Natalia S. Egorova, Nikita D. Timofeev, Ekaterina N. Spirova, Elizaveta Yu. Tufanova, Andrei E. Siniavin, Denis S. Kudryavtsev, Igor E. Kasheverov, Marios Zouridakis, Ramaz Katsarava, Nino Zavradashvili, Ia Iagorshvili, Socrates J. Tzartos and Victor I. Tsetlin

Molecular Pharmacology November 2019, 96 (5) 664-673; DOI: https://doi.org/10.1124/mol.119.117713

Erratum

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Correction to “Identification of Abundant and Evolutionarily Conserved Opioid Receptor Circular RNAs in the Nervous System Modulated by Morphine”
Molecular Pharmacology November 2019, 96 (5) 526; DOI: https://doi.org/10.1124/mol.119.113977err

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