Rapid CommunicationMinireview—Computational Analysis of GPCRs
Understanding Peptide Binding in Class A G Protein-Coupled Receptors
Irina G. Tikhonova, Veronique Gigoux and Daniel Fourmy
Molecular Pharmacology November 2019, 96 (5) 550-561; DOI: https://doi.org/10.1124/mol.119.115915
Irina G. Tikhonova
School of Pharmacy, Medical Biology Centre, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom, (I.G.T.) and INSERM ERL1226-Receptology and Therapeutic Targeting of Cancers, Laboratoire de Physique et Chimie des Nano-Objets, CNRS UMR5215-INSA, Université de Toulouse III, Toulouse, France (V.G., D.F.)
Veronique Gigoux
School of Pharmacy, Medical Biology Centre, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom, (I.G.T.) and INSERM ERL1226-Receptology and Therapeutic Targeting of Cancers, Laboratoire de Physique et Chimie des Nano-Objets, CNRS UMR5215-INSA, Université de Toulouse III, Toulouse, France (V.G., D.F.)
Daniel Fourmy
School of Pharmacy, Medical Biology Centre, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom, (I.G.T.) and INSERM ERL1226-Receptology and Therapeutic Targeting of Cancers, Laboratoire de Physique et Chimie des Nano-Objets, CNRS UMR5215-INSA, Université de Toulouse III, Toulouse, France (V.G., D.F.)

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In this issue
Rapid CommunicationMinireview—Computational Analysis of GPCRs
Peptide Class A GPCRs
Irina G. Tikhonova, Veronique Gigoux and Daniel Fourmy
Molecular Pharmacology November 1, 2019, 96 (5) 550-561; DOI: https://doi.org/10.1124/mol.119.115915
Jump to section
- Article
- Abstract
- Introduction
- X-Ray Structures of GPCRs Bound to Peptides
- Class A Receptor Grouping with Peptide SAR and Hydrophilic Binding Site Residues as a Basis
- GPCRs Binding Peptides with the C-Terminal Free Carboxyl Group Interacting with the Helical Cavity
- GPCRs Binding Peptides with the C-Terminal Amidated Carboxyl Group Interacting with the Helical Cavity
- GPCRs Binding Peptides with the N-Terminal End Pointing to the Helical Bundle
- GPCRs Binding Cyclic Peptides with a Cyclic Part Important for Activity and the PAR Receptors
- Concluding Remarks
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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