Research ArticleArticle
Isoliquiritigenin, an Orally Available Natural FLT3 Inhibitor from Licorice, Exhibits Selective Anti–Acute Myeloid Leukemia Efficacy In Vitro and In Vivo
Zhi-Xing Cao, Yi Wen, Jun-Lin He, Shen-Zhen Huang, Fei Gao, Chuan-Jie Guo, Qing-Qing Liu, Shu-Wen Zheng, Dao-Yin Gong, Yu-Zhi Li, Ruo-Qi Zhang, Jian-Ping Chen and Cheng Peng
Molecular Pharmacology November 2019, 96 (5) 589-599; DOI: https://doi.org/10.1124/mol.119.116129
Zhi-Xing Cao
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Yi Wen
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Jun-Lin He
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Shen-Zhen Huang
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Fei Gao
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Chuan-Jie Guo
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Qing-Qing Liu
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Shu-Wen Zheng
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Dao-Yin Gong
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Yu-Zhi Li
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Ruo-Qi Zhang
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Jian-Ping Chen
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)
Cheng Peng
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Chengdu, China (Z.-X.C., J.-L.H., C.-J.G., S.-W.Z., D.-Y.G., Y.-Z.L., R.-Q.Z., J.-P.C., C.P.);School of Chinese Medicine, University of Hong Kong, Hong Kong, China (Y.W., F.G., Q.-Q.L., J.-P.C.); College, Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China (Y.W., F.G., Q.-Q.L., J.-P.C.); and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China (S.-Z.H.)

Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleArticle
Isoliquiritigenin Inhibits AML Cells via Targeting FLT3
Zhi-Xing Cao, Yi Wen, Jun-Lin He, Shen-Zhen Huang, Fei Gao, Chuan-Jie Guo, Qing-Qing Liu, Shu-Wen Zheng, Dao-Yin Gong, Yu-Zhi Li, Ruo-Qi Zhang, Jian-Ping Chen and Cheng Peng
Molecular Pharmacology November 1, 2019, 96 (5) 589-599; DOI: https://doi.org/10.1124/mol.119.116129
Research ArticleArticle
Isoliquiritigenin Inhibits AML Cells via Targeting FLT3
Zhi-Xing Cao, Yi Wen, Jun-Lin He, Shen-Zhen Huang, Fei Gao, Chuan-Jie Guo, Qing-Qing Liu, Shu-Wen Zheng, Dao-Yin Gong, Yu-Zhi Li, Ruo-Qi Zhang, Jian-Ping Chen and Cheng Peng
Molecular Pharmacology November 1, 2019, 96 (5) 589-599; DOI: https://doi.org/10.1124/mol.119.116129
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement