Table of Contents

Articles

• Open Access

  Potential Regulation of UGT2B10 and UGT2B7 by miR-485-5p in Human Liver

  Aimee K. Sutliff, Jian Shi, Christy J.W. Watson, Martina S. Hunt, Gang Chen, Hao-Jie Zhu and Philip Lazarus

  Molecular Pharmacology December 2019, 96 (6) 674-682; DOI: https://doi.org/10.1124/mol.119.115881
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  An Interhelical Salt Bridge Controls Flexibility and Inhibitor Potency for Regulators of G-protein Signaling Proteins 4, 8, and 19

  Vincent S. Shaw, Mohammadjavad Mohammadi, Josiah A. Quinn, Harish Vashisth and Richard R. Neubig

  Molecular Pharmacology December 2019, 96 (6) 683-691; DOI: https://doi.org/10.1124/mol.119.117176
• Open Access

  N-Terminal Modification of the Tetrapeptide Arg-Leu-Tyr-Glu, a Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Antagonist, Improves Antitumor Activity by Increasing its Stability against Serum Peptidases

  Jung-A Yun, Joohwan Kim, Yi-Yong Baek, Wonjin Park, Minsik Park, Suji Kim, Taesam Kim, Seunghwan Choi, Dooil Jeoung, Hansoo Lee, Moo-Ho Won, Ji-Yoon Kim, Kwon-Soo Ha, Young-Guen Kwon and Young-Myeong Kim

  Molecular Pharmacology December 2019, 96 (6) 692-701; DOI: https://doi.org/10.1124/mol.119.117234
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  Homologous Regulation of Mu Opioid Receptor Recycling by G_βγ, Protein Kinase C, and Receptor Phosphorylation

  Jennifer M. Kunselman, Amanda S. Zajac, Zara Y. Weinberg and Manojkumar A. Puthenveedu

  Molecular Pharmacology December 2019, 96 (6) 702-710; DOI: https://doi.org/10.1124/mol.119.117267
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  The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation

  Jianhong Yang, Wei Yan, Yong Li, Lu Niu, Haoyu Ye and Lijuan Chen

  Molecular Pharmacology December 2019, 96 (6) 711-719; DOI: https://doi.org/10.1124/mol.119.117812
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  Conformational Changes in the 5-HT_3A Receptor Extracellular Domain Measured by Voltage-Clamp Fluorometry

  Lachlan Munro, Lucy Kate Ladefoged, Vithushan Padmanathan, Signe Andersen, Birgit Schiøtt and Anders S. Kristensen

  Molecular Pharmacology December 2019, 96 (6) 720-734; DOI: https://doi.org/10.1124/mol.119.116657
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  Loss-of-Function Mutations in Human Regulator of G Protein Signaling RGS2 Differentially Regulate Pharmacological Reactivity of Resistance Vasculature

  Hoa T.N. Phan, William F. Jackson, Vincent S. Shaw, Stephanie W. Watts and Richard R. Neubig

  Molecular Pharmacology December 2019, 96 (6) 826-834; DOI: https://doi.org/10.1124/mol.119.116822
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  Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors

  Charlotte Stenum-Berg, Maria Musgaard, Sergei Chavez-Abiega, Christine L. Thisted, Lorenzo Barrella, Philip C. Biggin and Anders S. Kristensen

  Molecular Pharmacology December 2019, 96 (6) 835-850; DOI: https://doi.org/10.1124/mol.119.116871
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  Comparative Docking to Distinct G Protein–Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy

  Magdalena M. Scharf, Moritz Bünemann, Jillian G. Baker and Peter Kolb

  Molecular Pharmacology December 2019, 96 (6) 851-861; DOI: https://doi.org/10.1124/mol.119.117515
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  Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines

  Trista K. Hinz, Emily K. Kleczko, Katherine R. Singleton, Jacob Calhoun, Lindsay A. Marek, Jihye Kim, Aik Choon Tan and Lynn E. Heasley

  Molecular Pharmacology December 2019, 96 (6) 862-870; DOI: https://doi.org/10.1124/mol.119.117804