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Research ArticleArticle

Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors

Charlotte Stenum-Berg, Maria Musgaard, Sergei Chavez-Abiega, Christine L. Thisted, Lorenzo Barrella, Philip C. Biggin and Anders S. Kristensen
Molecular Pharmacology December 2019, 96 (6) 835-850; DOI: https://doi.org/10.1124/mol.119.116871
Charlotte Stenum-Berg
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.)
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Maria Musgaard
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.)
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Sergei Chavez-Abiega
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.)
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Christine L. Thisted
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.)
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Lorenzo Barrella
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.)
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Philip C. Biggin
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.)
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Anders S. Kristensen
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.)
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Article Information

vol. 96 no. 6 835-850
DOI 
https://doi.org/10.1124/mol.119.116871
PubMed 
31582576

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 30, 2019
  • Accepted October 1, 2019
  • Published online November 15, 2019.

Article Versions

  • Earlier version (October 3, 2019 - 06:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Charlotte Stenum-Berg,
  2. Maria Musgaard1,
  3. Sergei Chavez-Abiega,
  4. Christine L. Thisted,
  5. Lorenzo Barrella,
  6. Philip C. Biggin, and
  7. Anders S. Kristensen
  1. Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.)
  1. Address correspondence to:
    Anders S. Kristensen, Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. E-mail: ask{at}sund.ku.dk
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Molecular Pharmacology: 96 (6)
Molecular Pharmacology
Vol. 96, Issue 6
1 Dec 2019
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Research ArticleArticle

Binding of Negative Allosteric Modulators in AMPA Receptors

Charlotte Stenum-Berg, Maria Musgaard, Sergei Chavez-Abiega, Christine L. Thisted, Lorenzo Barrella, Philip C. Biggin and Anders S. Kristensen
Molecular Pharmacology December 1, 2019, 96 (6) 835-850; DOI: https://doi.org/10.1124/mol.119.116871

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Research ArticleArticle

Binding of Negative Allosteric Modulators in AMPA Receptors

Charlotte Stenum-Berg, Maria Musgaard, Sergei Chavez-Abiega, Christine L. Thisted, Lorenzo Barrella, Philip C. Biggin and Anders S. Kristensen
Molecular Pharmacology December 1, 2019, 96 (6) 835-850; DOI: https://doi.org/10.1124/mol.119.116871
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