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Research ArticleSpecial Section on New Opportunities in Targeting WNT Signaling – Minireview
Open Access

Wnt Signaling and Drug Resistance in Cancer

Zheng Zhong and David M. Virshup
Molecular Pharmacology February 2020, 97 (2) 72-89; DOI: https://doi.org/10.1124/mol.119.117978
Zheng Zhong
Department of Physiology, National University of Singapore, Singapore, Singapore (Z.Z.); Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore (Z.Z., D.M.V.); and Department of Pediatrics, Duke University, Durham, North Carolina (D.M.V.)
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David M. Virshup
Department of Physiology, National University of Singapore, Singapore, Singapore (Z.Z.); Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore (Z.Z., D.M.V.); and Department of Pediatrics, Duke University, Durham, North Carolina (D.M.V.)
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Article Information

vol. 97 no. 2 72-89
DOI 
https://doi.org/10.1124/mol.119.117978
PubMed 
31787618

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 17, 2019
  • Accepted November 21, 2019
  • Published online January 9, 2020.

Article Versions

  • Earlier version (December 1, 2019 - 05:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Zheng Zhong and
  2. David M. Virshup
  1. Department of Physiology, National University of Singapore, Singapore, Singapore (Z.Z.); Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore (Z.Z., D.M.V.); and Department of Pediatrics, Duke University, Durham, North Carolina (D.M.V.)
  1. Address correspondence to:
    David M. Virshup, Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. E-mail: david.virshup{at}duke-nus.edu.sg
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Molecular Pharmacology: 97 (2)
Molecular Pharmacology
Vol. 97, Issue 2
1 Feb 2020
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Research ArticleSpecial Section on New Opportunities in Targeting WNT Signaling – Minireview

Wnt Signaling and Drug Resistance in Cancer

Zheng Zhong and David M. Virshup
Molecular Pharmacology February 1, 2020, 97 (2) 72-89; DOI: https://doi.org/10.1124/mol.119.117978

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Research ArticleSpecial Section on New Opportunities in Targeting WNT Signaling – Minireview

Wnt Signaling and Drug Resistance in Cancer

Zheng Zhong and David M. Virshup
Molecular Pharmacology February 1, 2020, 97 (2) 72-89; DOI: https://doi.org/10.1124/mol.119.117978
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  • Article
    • Abstract
    • Introduction
    • Wnt Signaling Pathway
    • Aberrant Wnt Signaling in Cancer and Pharmacological Targeting of Wnt Signaling
    • Wnt Signaling Mediated Resistance in Cancer Therapy
    • Resistance to Wnt Pathway Blockade in Normal Tissue and Wnt-Driven Cancer
    • Concluding Remarks
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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  • Class F Receptors as Molecular Machines
  • WNT Signaling in Cardiomyocyte Proliferation
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