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Molecular Pharmacology

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Table of Contents

March 01, 2020; Volume 97,Issue 3

Articles

  • You have access
    Structural Determinants of Kv7.5 Potassium Channels That Confer Changes in Phosphatidylinositol 4,5-Bisphosphate (PIP2) Affinity and Signaling Sensitivities in Smooth Muscle Cells
    Lyubov I. Brueggemann, Leanne L. Cribbs and Kenneth L. Byron
    Molecular Pharmacology March 2020, 97 (3) 145-158; DOI: https://doi.org/10.1124/mol.119.117192
  • You have access
    hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Human Leukemia K562 Cells with Acquired Resistance to Etoposide
    Evan E. Kania, Jessika Carvajal-Moreno, Victor A. Hernandez, Anthony English, Jonathan L. Papa, Nicholas Shkolnikov, Hatice Gulcin Ozer, Ayse Selen Yilmaz, Jack C. Yalowich and Terry S. Elton
    Molecular Pharmacology March 2020, 97 (3) 159-170; DOI: https://doi.org/10.1124/mol.119.118315
  • Bupropion Inhibits Serotonin Type 3AB Heteromeric Channels at Clinically Relevant Concentrations
    Open Access
    Bupropion Inhibits Serotonin Type 3AB Heteromeric Channels at Clinically Relevant Concentrations
    Antonia G. Stuebler and Michaela Jansen
    Molecular Pharmacology March 2020, 97 (3) 171-179; DOI: https://doi.org/10.1124/mol.119.118349
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    CITCO Directly Binds to and Activates Human Pregnane X Receptor
    Wenwei Lin, Monicah Bwayi, Jing Wu, Yongtao Li, Sergio C. Chai, Andrew D. Huber and Taosheng Chen
    Molecular Pharmacology March 2020, 97 (3) 180-190; DOI: https://doi.org/10.1124/mol.119.118513
  • Ser100-Phosphorylated ROR<em>α</em> Orchestrates CAR and HNF4<em>α</em> to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6
    You have access
    Ser100-Phosphorylated RORα Orchestrates CAR and HNF4α to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6
    Muluneh Fashe, Takuyu Hashiguchi, Masahiko Negishi and Tatsuya Sueyoshi
    Molecular Pharmacology March 2020, 97 (3) 191-201; DOI: https://doi.org/10.1124/mol.119.118273
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    Interactions between Atorvastatin and the Farnesoid X Receptor Impair Insulinotropic Effects of Bile Acids and Modulate Diabetogenic Risk
    Theresa Hoffmeister, Julia Kaiser, Simon Lüdtke, Gisela Drews and Martina Düfer
    Molecular Pharmacology March 2020, 97 (3) 202-211; DOI: https://doi.org/10.1124/mol.119.118083
  • The Peroxisome Proliferator–Activated Receptor (PPAR)-<em>γ</em> Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPAR<em>δ</em> and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages
    You have access
    The Peroxisome Proliferator–Activated Receptor (PPAR)-γ Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPARδ and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages
    Martin Schubert, Stefanie Becher, Maria Wallert, Marten B. Maeß, Masoumeh Abhari, Knut Rennert, Alexander S. Mosig, Silke Große, Regine Heller, Michael Grün and Stefan Lorkowski
    Molecular Pharmacology March 2020, 97 (3) 212-225; DOI: https://doi.org/10.1124/mol.119.117887
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    Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils
    Jennifer N. Cash, Naincy R. Chandan, Alan Y. Hsu, Prateek V. Sharma, Qing Deng, Alan V. Smrcka and John J.G. Tesmer
    Molecular Pharmacology March 2020, 97 (3) 226-236; DOI: https://doi.org/10.1124/mol.119.117556
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In this issue

Molecular Pharmacology: 97 (3)
Molecular Pharmacology
Vol. 97, Issue 3
1 Mar 2020
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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