Research ArticleArticle
Structures of Mycobacterium tuberculosis Penicillin-Binding Protein 3 in Complex with Five β-Lactam Antibiotics Reveal Mechanism of Inactivation
Zuokun Lu, Han Wang, Aili Zhang, Xiang Liu, Weihong Zhou, Cheng Yang, Luke Guddat, Haitao Yang, Christopher J. Schofield and Zihe Rao
Molecular Pharmacology April 2020, 97 (4) 287-294; DOI: https://doi.org/10.1124/mol.119.118042
Zuokun Lu
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
Han Wang
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
Aili Zhang
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
Xiang Liu
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
Weihong Zhou
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
Cheng Yang
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
Luke Guddat
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
Haitao Yang
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
Christopher J. Schofield
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
Zihe Rao
Key Laboratory of Biomarker Based Rapid-detection Technology for Food Safety of Henan Province, Xuchang University, Xuchang, Henan, China (Z.L., A.Z.); College of Life Sciences (Z.L., H.W., W.Z. and Z.R.) and College of Pharmacy (X.L., C.Y.), Nankai University, Tianjin, China; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia (L.G.); School of Life Sciences, Tianjin University, Tianjin, China (H.Y.); University of Oxford, Chemistry Research Laboratory, Oxford, United Kingdom (C.J.S.); National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China (Z.R.); and Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China (Z.R.)
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Research ArticleArticle
Structures of MtbPBP3 Complexed with β-Lactams Antibiotics
Zuokun Lu, Han Wang, Aili Zhang, Xiang Liu, Weihong Zhou, Cheng Yang, Luke Guddat, Haitao Yang, Christopher J. Schofield and Zihe Rao
Molecular Pharmacology April 1, 2020, 97 (4) 287-294; DOI: https://doi.org/10.1124/mol.119.118042
Research ArticleArticle
Structures of MtbPBP3 Complexed with β-Lactams Antibiotics
Zuokun Lu, Han Wang, Aili Zhang, Xiang Liu, Weihong Zhou, Cheng Yang, Luke Guddat, Haitao Yang, Christopher J. Schofield and Zihe Rao
Molecular Pharmacology April 1, 2020, 97 (4) 287-294; DOI: https://doi.org/10.1124/mol.119.118042
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