Molecular Pharmacology: 98 (4)

October 01, 2020; Volume 98,Issue 4

Special Section on 50 Years of Opioid Research

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Editorial: 50 Years of Opioid Research and the International Narcotics Research Conference
Manojkumar A. Puthenveedu

Molecular Pharmacology October 2020, 98 (4) 386-388; DOI: https://doi.org/10.1124/molpharm.120.000132
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Opioid Research: Past and Future
Rita J. Valentino and Nora D. Volkow

Molecular Pharmacology October 2020, 98 (4) 389-391; DOI: https://doi.org/10.1124/molpharm.120.000093
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A Concise Review of Concepts in Opioid Pharmacology up to the Discovery of Endogenous Opioids
Brian M. Cox

Molecular Pharmacology October 2020, 98 (4) 392-400; DOI: https://doi.org/10.1124/mol.120.119420
Open Access
Recent Progress in Opioid Research from an Electrophysiological Perspective
William T. Birdsong and John T. Williams

Molecular Pharmacology October 2020, 98 (4) 401-409; DOI: https://doi.org/10.1124/mol.119.119040
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Intrinsic Efficacy of Opioid Ligands and Its Importance for Apparent Bias, Operational Analysis, and Therapeutic Window
Alexander Gillis, Varun Sreenivasan and Macdonald J. Christie

Molecular Pharmacology October 2020, 98 (4) 410-424; DOI: https://doi.org/10.1124/mol.119.119214
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Opioid Pharmacology under the Microscope
Damien Jullié, Arisbel B. Gondin, Mark von Zastrow and Meritxell Canals

Molecular Pharmacology October 2020, 98 (4) 425-432; DOI: https://doi.org/10.1124/mol.119.119321
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Pain, Motivation, Migraine, and the Microbiome: New Frontiers for Opioid Systems and Disease
Kyle E. Parker, Elizabeth Sugiarto, Anna M.W. Taylor, Amynah A. Pradhan and Ream Al-Hasani

Molecular Pharmacology October 2020, 98 (4) 433-444; DOI: https://doi.org/10.1124/mol.120.119438
Open Access
Bidirectional Relationship between Opioids and Disrupted Sleep: Putative Mechanisms
D. Eacret, S.C. Veasey and J.A. Blendy

Molecular Pharmacology October 2020, 98 (4) 445-453; DOI: https://doi.org/10.1124/mol.119.119107
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Neprilysin Controls the Synaptic Activity of Neuropeptides in the Intercalated Cells of the Amygdala
G.C. Gregoriou, S.D. Patel, B.L. Winters and E.E. Bagley

Molecular Pharmacology October 2020, 98 (4) 454-461; DOI: https://doi.org/10.1124/mol.119.119370
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Unique Pharmacological Properties of the Kappa Opioid Receptor Signaling Through Gαz as Shown with Bioluminescence Resonance Energy Transfer
Miriam E. Barnett, Brian I. Knapp and Jean M. Bidlack

Molecular Pharmacology October 2020, 98 (4) 462-474; DOI: https://doi.org/10.1124/mol.120.119404
Open Access
Atomic-Level Characterization of the Methadone-Stabilized Active Conformation of µ-Opioid Receptor
Abhijeet Kapoor, Davide Provasi and Marta Filizola

Molecular Pharmacology October 2020, 98 (4) 475-486; DOI: https://doi.org/10.1124/mol.119.119339
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Spinal Opioid Tolerance Depends upon Platelet-Derived Growth Factor Receptor-β Signaling, Not μ-Opioid Receptor Internalization
S. Puig, K.E. Barker, S.R. Szott, P.T. Kann, J.S. Morris and H.B. Gutstein

Molecular Pharmacology October 2020, 98 (4) 487-496; DOI: https://doi.org/10.1124/mol.120.119552
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Chronic Treatment with Morphine Disrupts Acute Kinase-Dependent Desensitization of GPCRs
Emily R. Leff, Seksiri Arttamangkul and John T. Williams

Molecular Pharmacology October 2020, 98 (4) 497-507; DOI: https://doi.org/10.1124/mol.119.119362
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Fentanyl-Induced Block of hERG Channels Is Exacerbated by Hypoxia, Hypokalemia, Alkalosis, and the Presence of hERG1b
Jared N. Tschirhart and Shetuan Zhang

Molecular Pharmacology October 2020, 98 (4) 508-517; DOI: https://doi.org/10.1124/mol.119.119271
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A Truncated Six Transmembrane Splice Variant MOR-1G Enhances Expression of the Full-Length Seven Transmembrane μ-Opioid Receptor through Heterodimerization
Tiffany Zhang, Jin Xu and Ying-Xian Pan

Molecular Pharmacology October 2020, 98 (4) 518-527; DOI: https://doi.org/10.1124/mol.120.119453

Editorial

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“Emerging Concepts”: New Article Category in Molecular Pharmacology
David A. Gewirtz

Molecular Pharmacology October 2020, 98 (4) 350; DOI: https://doi.org/10.1124/molpharm.120.000133

Emerging Concepts

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Weak Microbial Metabolites: a Treasure Trove for Using Biomimicry to Discover and Optimize Drugs
Zdenek Dvorak, Max Klapholz, Thomas P. Burris, Benjamin P. Willing, Antimo Gioiello, Roberto Pellicciari, Francesco Galli, John March, Stephen J. O’Keefe, R. Balfour Sartor, Chang H. Kim, Maayan Levy and Sridhar Mani

Molecular Pharmacology October 2020, 98 (4) 343-349; DOI: https://doi.org/10.1124/molpharm.120.000035

Minireview

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Targeting Vesicular Glutamate Transporter Machinery: Implications on Metabotropic Glutamate Receptor 5 Signaling and Behavior
Karim S. Ibrahim, Khaled S. Abd-Elrahman, Salah El Mestikawy and Stephen S.G. Ferguson

Molecular Pharmacology October 2020, 98 (4) 314-327; DOI: https://doi.org/10.1124/molpharm.120.000089

Articles

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Analysis of Modulation of the ρ1 GABA_A Receptor by Combinations of Inhibitory and Potentiating Neurosteroids Reveals Shared and Distinct Binding Sites
Allison L. Germann, David E. Reichert, Ariel B. Burbridge, Spencer R. Pierce, Alex S. Evers, Joe Henry Steinbach and Gustav Akk

Molecular Pharmacology October 2020, 98 (4) 280-291; DOI: https://doi.org/10.1124/mol.120.119842
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Differing Activity Profiles of the Stereoisomers of 2,3,5,6TMP-TQS, a Putative Silent Allosteric Modulator of α7 nAChR
Roger L. Papke, Sumanta Garai, Clare Stokes, Nicole A. Horenstein, Arthur D. Zimmerman, Khalil A. Abboud and Ganesh A. Thakur

Molecular Pharmacology October 2020, 98 (4) 292-302; DOI: https://doi.org/10.1124/mol.120.119958
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Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA_A Receptor: Relating Occupancy to State Functions
Gustav Akk, Allison L. Germann, Yusuke Sugasawa, Spencer R. Pierce, Alex S. Evers and Joe Henry Steinbach

Molecular Pharmacology October 2020, 98 (4) 303-313; DOI: https://doi.org/10.1124/molpharm.120.000066
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Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives
Lu Wenchi Corrie, Clare Stokes, Jenny L. Wilkerson, F. Ivy Carroll, Lance R. McMahon and Roger L. Papke

Molecular Pharmacology October 2020, 98 (4) 328-342; DOI: https://doi.org/10.1124/molpharm.120.000037
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Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice
Monica Aleman, Rui Zhang, Wei Feng, Lihong Qi, Jose R. Lopez, Chelsea Crowe, Yao Dong, Genady Cherednichenko and Isaac N. Pessah

Molecular Pharmacology October 2020, 98 (4) 351-363; DOI: https://doi.org/10.1124/mol.120.119412
Open Access
Pharmacology and Molecular Mechanisms of Clinically Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for the Treatment of Endocrine-Resistant Breast Cancer
Balkees Abderrahman, Philipp Y. Maximov, Ramona F. Curpan, Jay S. Hanspal, Ping Fan, Rui Xiong, Debra A. Tonetti, Gregory R.J. Thatcher and V. Craig Jordan

Molecular Pharmacology October 2020, 98 (4) 364-381; DOI: https://doi.org/10.1124/molpharm.120.000054

Letter to the editor

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Commentary on: “Does COVID19 Infect the Brain? If So, Smokers Might Be at a Higher Risk”
Robert C. Speth

Molecular Pharmacology October 2020, 98 (4) 382-383; DOI: https://doi.org/10.1124/molpharm.120.000049

Response to Letter to the Editor

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Response to Comments on “Does COVID19 Infect the Brain? If So, Smokers Might Be at a Higher Risk”
N. Kabbani and J.L. Olds

Molecular Pharmacology October 2020, 98 (4) 384-385; DOI: https://doi.org/10.1124/molpharm.120.000120

Erratum

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Correction to “Pharmacology and Molecular Mechanisms of Clinically Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for the Treatment of Endocrine-Resistant Breast Cancer”
Molecular Pharmacology October 2020, 98 (4) 528; DOI: https://doi.org/10.1124/molpharm.120.000054err

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Special Section on 50 Years of Opioid Research

Editorial

Emerging Concepts

Minireview

Articles

Letter to the editor

Response to Letter to the Editor

Erratum

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