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Molecular Pharmacology

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Research ArticleArticle

Differing Activity Profiles of the Stereoisomers of 2,3,5,6TMP-TQS, a Putative Silent Allosteric Modulator of α7 nAChR

Roger L. Papke, Sumanta Garai, Clare Stokes, Nicole A. Horenstein, Arthur D. Zimmerman, Khalil A. Abboud and Ganesh A. Thakur
Molecular Pharmacology October 2020, 98 (4) 292-302; DOI: https://doi.org/10.1124/mol.120.119958
Roger L. Papke
Departments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.)
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Sumanta Garai
Departments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.)
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Clare Stokes
Departments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.)
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Nicole A. Horenstein
Departments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.)
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Arthur D. Zimmerman
Departments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.)
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Khalil A. Abboud
Departments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.)
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Ganesh A. Thakur
Departments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.)
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Article Information

vol. 98 no. 4 292-302
DOI 
https://doi.org/10.1124/mol.120.119958
PubMed 
32690627

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 3, 2020
  • Accepted July 13, 2020
  • Published online September 1, 2020.

Article Versions

  • Earlier version (July 20, 2020 - 11:54).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Roger L. Papke,
  2. Sumanta Garai,
  3. Clare Stokes,
  4. Nicole A. Horenstein,
  5. Arthur D. Zimmerman,
  6. Khalil A. Abboud, and
  7. Ganesh A. Thakur
  1. Departments of Pharmacology and Therapeutics (R.L.P., C.S., A.D.Z.) and Chemistry (N.A.H., K.A.A.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.)
  1. Address correspondence to:
    Roger L. Papke, Department of Pharmacology and Therapeutics, University of Florida, P.O. Box 100267, Gainesville, FL 32610-0267. E-mail: rlpapke{at}ufl.edu; or
  2. Ganesh A. Thakur, Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115. E-mail: g.thakur{at}northeastern.edu
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Molecular Pharmacology: 98 (4)
Molecular Pharmacology
Vol. 98, Issue 4
1 Oct 2020
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Research ArticleArticle

Stereochemistry of α7 nAChR PAMs

Roger L. Papke, Sumanta Garai, Clare Stokes, Nicole A. Horenstein, Arthur D. Zimmerman, Khalil A. Abboud and Ganesh A. Thakur
Molecular Pharmacology October 1, 2020, 98 (4) 292-302; DOI: https://doi.org/10.1124/mol.120.119958

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Research ArticleArticle

Stereochemistry of α7 nAChR PAMs

Roger L. Papke, Sumanta Garai, Clare Stokes, Nicole A. Horenstein, Arthur D. Zimmerman, Khalil A. Abboud and Ganesh A. Thakur
Molecular Pharmacology October 1, 2020, 98 (4) 292-302; DOI: https://doi.org/10.1124/mol.120.119958
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