Molecular Pharmacology: 98 (6)

December 01, 2020; Volume 98,Issue 6

Special Section on RGS Proteins in Health and Disease

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RGS Proteins as Critical Regulators of Motor Function and Their Implications in Parkinson’s Disease
Katelin E. Ahlers-Dannen, Mackenzie M. Spicer and Rory A. Fisher

Molecular Pharmacology December 2020, 98 (6) 730-738; DOI: https://doi.org/10.1124/mol.119.118836
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Regulators of G Protein Signaling in Analgesia and Addiction
Farhana Sakloth, Claire Polizu, Feodora Bertherat and Venetia Zachariou

Molecular Pharmacology December 2020, 98 (6) 739-750; DOI: https://doi.org/10.1124/mol.119.119206
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Emerging Roles for Regulator of G Protein Signaling 2 in (Patho)physiology
Harrison J. McNabb, Qian Zhang and Benita Sjögren

Molecular Pharmacology December 2020, 98 (6) 751-760; DOI: https://doi.org/10.1124/molpharm.120.000111

Accelerated Communication

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Reduced Activation of the Synaptic-Type GABA_A Receptor Following Prolonged Exposure to Low Concentrations of Agonists: Relationship between Tonic Activity and Desensitization
Spencer R. Pierce, Allison L. Germann, Alex S. Evers, Joe Henry Steinbach and Gustav Akk

Molecular Pharmacology December 2020, 98 (6) 762-769; DOI: https://doi.org/10.1124/molpharm.120.000088

Articles

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Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin
Mateusz P. Czub, Adam M. Boulton, Ettore J. Rastelli, Nikhil R. Tasker, Taber S. Maskrey, Isabella K. Blanco, Kelley E. McQueeney, John H. Bushweller, Wladek Minor, Peter Wipf, Elizabeth R. Sharlow and John S. Lazo

Molecular Pharmacology December 2020, 98 (6) 648-657; DOI: https://doi.org/10.1124/molpharm.120.000131
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The Influence of Tobacco Smoke/Nicotine on CYP2A Expression in Human and African Green Monkey Lungs
Yuan Gao, Sharon Miksys, Roberta M. Palmour and Rachel F. Tyndale

Molecular Pharmacology December 2020, 98 (6) 658-668; DOI: https://doi.org/10.1124/molpharm.120.000100
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GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress
Yu Kato, Kazuhiro Kunimasa, Mizuki Takahashi, Ayaka Harada, Ikuko Nagasawa, Masanori Osawa, Yoshikazu Sugimoto and Akihiro Tomida

Molecular Pharmacology December 2020, 98 (6) 669-676; DOI: https://doi.org/10.1124/molpharm.120.000070
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N-Terminal Targeting of Regulator of G Protein Signaling Protein 2 for F-Box Only Protein 44–Mediated Proteasomal Degradation
Harrison J. McNabb, Stephanie Gonzalez, Christine S. Muli and Benita Sjögren

Molecular Pharmacology December 2020, 98 (6) 677-685; DOI: https://doi.org/10.1124/molpharm.120.000061
Open Access
MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis
Mei-Juan Tu, Zhijian Duan, Zhenzhen Liu, Chao Zhang, Richard J. Bold, Frank J. Gonzalez, Edward J. Kim and Ai-Ming Yu

Molecular Pharmacology December 2020, 98 (6) 686-694; DOI: https://doi.org/10.1124/molpharm.120.000130
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Allosterically Potentiated α7 Nicotinic Acetylcholine Receptors: Reduced Calcium Permeability and Current-Independent Control of Intracellular Calcium
Douglas R. Miller, Habibeh Khoshbouei, Sumanta Garai, Lucas N. Cantwell, Clare Stokes, Ganesh Thakur and Roger L. Papke

Molecular Pharmacology December 2020, 98 (6) 695-709; DOI: https://doi.org/10.1124/molpharm.120.000012
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Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity
Pramod C. Nair, Nuy Chau, Ross A. McKinnon and John O. Miners

Molecular Pharmacology December 2020, 98 (6) 710-718; DOI: https://doi.org/10.1124/molpharm.120.000104
Open Access
Glutamate, d-(−)-2-Amino-5-Phosphonopentanoic Acid, and N-Methyl-d-Aspartate Do Not Directly Modulate Glycine Receptors
Karin R. Aubrey, Diba Sheipouri, Thomas Balle, Robert J. Vandenberg and Yo Otsu

Molecular Pharmacology December 2020, 98 (6) 719-729; DOI: https://doi.org/10.1124/molpharm.120.000127
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Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole
Vandna Sharma, Brian Shing, Lilian Hernandez-Alvarez, Anjan Debnath and Larissa M. Podust

Molecular Pharmacology December 2020, 98 (6) 770-780; DOI: https://doi.org/10.1124/molpharm.120.000092