Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Review ArticleMinireview

Dysregulation of Angiotensin Converting Enzyme 2 Expression and Function in Comorbid Disease Conditions Possibly Contributes to Coronavirus Infectious Disease 2019 Complication Severity

Safaa H Hammoud, Zena Wehbe, Samar Abdelhady, Firas Kobeissy, Ali H. Eid and Ahmed F. El-Yazbi
Molecular Pharmacology January 2021, 99 (1) 17-28; DOI: https://doi.org/10.1124/molpharm.120.000119
Safaa H Hammoud
Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut, Lebanon (S.H.); Departments of Biology (Z.W.), Biochemistry and Molecular Genetics (F.K.), and Pharmacology and Toxicology (A.H.E., A.F.E.-Y.), American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy (A.F.E.-Y.) and Faculty of Medicine (S.A.), Alexandria University, Alexandria, Egypt; and Department of Basic Medical Sciences, College of Medicine, and Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar (A.H.E.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zena Wehbe
Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut, Lebanon (S.H.); Departments of Biology (Z.W.), Biochemistry and Molecular Genetics (F.K.), and Pharmacology and Toxicology (A.H.E., A.F.E.-Y.), American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy (A.F.E.-Y.) and Faculty of Medicine (S.A.), Alexandria University, Alexandria, Egypt; and Department of Basic Medical Sciences, College of Medicine, and Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar (A.H.E.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Samar Abdelhady
Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut, Lebanon (S.H.); Departments of Biology (Z.W.), Biochemistry and Molecular Genetics (F.K.), and Pharmacology and Toxicology (A.H.E., A.F.E.-Y.), American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy (A.F.E.-Y.) and Faculty of Medicine (S.A.), Alexandria University, Alexandria, Egypt; and Department of Basic Medical Sciences, College of Medicine, and Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar (A.H.E.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Firas Kobeissy
Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut, Lebanon (S.H.); Departments of Biology (Z.W.), Biochemistry and Molecular Genetics (F.K.), and Pharmacology and Toxicology (A.H.E., A.F.E.-Y.), American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy (A.F.E.-Y.) and Faculty of Medicine (S.A.), Alexandria University, Alexandria, Egypt; and Department of Basic Medical Sciences, College of Medicine, and Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar (A.H.E.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ali H. Eid
Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut, Lebanon (S.H.); Departments of Biology (Z.W.), Biochemistry and Molecular Genetics (F.K.), and Pharmacology and Toxicology (A.H.E., A.F.E.-Y.), American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy (A.F.E.-Y.) and Faculty of Medicine (S.A.), Alexandria University, Alexandria, Egypt; and Department of Basic Medical Sciences, College of Medicine, and Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar (A.H.E.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: ae81@aub.edu.lb
Ahmed F. El-Yazbi
Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut, Lebanon (S.H.); Departments of Biology (Z.W.), Biochemistry and Molecular Genetics (F.K.), and Pharmacology and Toxicology (A.H.E., A.F.E.-Y.), American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy (A.F.E.-Y.) and Faculty of Medicine (S.A.), Alexandria University, Alexandria, Egypt; and Department of Basic Medical Sciences, College of Medicine, and Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar (A.H.E.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: ae88@aub.edu.lb
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Figures & Data

Tables

    • View popup
    TABLE 1

    Potential proteins that may be involved in S protein processing and ACE2 interaction

    Protein Implicated in SARS-CoV-2 EntryBLASTp Results in Human Protein Data BaseSequence Identity (Filter: min ∼50%)Relevance (UniProKb Data Base)
    Furin proteaseCadherin-related family member 455.6%Expressed in lung, uterine tube, testis (similar pattern to ACE2 prominent distribution) single-pass transmembrane protein.
    Isoform 7 of tumor necrosis factor receptor superfamily member 2550%Interacts with receptor adapter protein TRADD and activates NF-κB, which are involved in inflammatory-induced apoptosis. May play a role in regulating lymphocyte homeostasis.

    BLASTp, protein-protein basic local alignment research tool; NF-kB, nuclear factor kB; TRADD, tumor necrosis factor type 1-associated DEATH domain protein

    PreviousNext
    Back to top

    In this issue

    Molecular Pharmacology: 99 (1)
    Molecular Pharmacology
    Vol. 99, Issue 1
    1 Jan 2021
    • Table of Contents
    • Table of Contents (PDF)
    • About the Cover
    • Index by author
    • Editorial Board (PDF)
    • Front Matter (PDF)
    Download PDF
    Article Alerts
    Sign In to Email Alerts with your Email Address
    Email Article

    Thank you for sharing this Molecular Pharmacology article.

    NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

    Enter multiple addresses on separate lines or separate them with commas.
    Dysregulation of Angiotensin Converting Enzyme 2 Expression and Function in Comorbid Disease Conditions Possibly Contributes to Coronavirus Infectious Disease 2019 Complication Severity
    (Your Name) has forwarded a page to you from Molecular Pharmacology
    (Your Name) thought you would be interested in this article in Molecular Pharmacology.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Citation Tools
    Review ArticleMinireview

    Alteration of ACE2 Expression Affects COVID-19 Severity

    Safaa H Hammoud, Zena Wehbe, Samar Abdelhady, Firas Kobeissy, Ali H. Eid and Ahmed F. El-Yazbi
    Molecular Pharmacology January 1, 2021, 99 (1) 17-28; DOI: https://doi.org/10.1124/molpharm.120.000119

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Review ArticleMinireview

    Alteration of ACE2 Expression Affects COVID-19 Severity

    Safaa H Hammoud, Zena Wehbe, Samar Abdelhady, Firas Kobeissy, Ali H. Eid and Ahmed F. El-Yazbi
    Molecular Pharmacology January 1, 2021, 99 (1) 17-28; DOI: https://doi.org/10.1124/molpharm.120.000119
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    Jump to section

    • Article
      • Abstract
      • Introduction
      • ACE2 Tissue Distribution
      • The Effect of Comorbid ACE2 Dysregulation on COVID-19–Associated Symptoms
      • ACE2 Protein Interactions and Associated Signaling Pathways
      • Concluding Remarks
      • Authorship Contributions
      • Footnotes
      • Abbreviations
      • References
    • Figures & Data
    • Info & Metrics
    • eLetters
    • PDF

    Related Articles

    Cited By...

    More in this TOC Section

    • Inflammation-Resolving Actions of Lenabasum: Mechanisms
    • Proteomic analysis of GPCR cell biology
    • Vasoprotective Axis of RAS in Progenitor Cells
    Show more Minireview

    Similar Articles

    • Home
    • Alerts
    Facebook   Twitter   LinkedIn   RSS

    Navigate

    • Current Issue
    • Fast Forward by date
    • Fast Forward by section
    • Latest Articles
    • Archive
    • Search for Articles
    • Feedback
    • ASPET

    More Information

    • About Molecular Pharmacology
    • Editorial Board
    • Instructions to Authors
    • Submit a Manuscript
    • Customized Alerts
    • RSS Feeds
    • Subscriptions
    • Permissions
    • Terms & Conditions of Use

    ASPET's Other Journals

    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    ISSN 1521-0111 (Online)

    Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics