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Research ArticleArticle

Short-Term Acyl-CoA:Cholesterol Acyltransferase Inhibition, Combined with Apoprotein A1 Overexpression, Promotes Atherosclerosis Inflammation Resolution in Mice

Jaume Amengual, Yoscar Ogando, Cyrus Nikain, Alexandra Quezada, Kun Qian, Tomas Vaisar and Edward A. Fisher
Molecular Pharmacology March 2021, 99 (3) 175-183; DOI: https://doi.org/10.1124/molpharm.120.000108
Jaume Amengual
Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, New York (J.A., Y.O, C.N., A.Q., K.Q., E.A.F); Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Champaign, Illinois (.J.A.); Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington (T.V.); and Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York (K.Q.)
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Yoscar Ogando
Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, New York (J.A., Y.O, C.N., A.Q., K.Q., E.A.F); Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Champaign, Illinois (.J.A.); Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington (T.V.); and Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York (K.Q.)
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Cyrus Nikain
Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, New York (J.A., Y.O, C.N., A.Q., K.Q., E.A.F); Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Champaign, Illinois (.J.A.); Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington (T.V.); and Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York (K.Q.)
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Alexandra Quezada
Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, New York (J.A., Y.O, C.N., A.Q., K.Q., E.A.F); Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Champaign, Illinois (.J.A.); Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington (T.V.); and Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York (K.Q.)
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Kun Qian
Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, New York (J.A., Y.O, C.N., A.Q., K.Q., E.A.F); Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Champaign, Illinois (.J.A.); Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington (T.V.); and Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York (K.Q.)
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Tomas Vaisar
Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, New York (J.A., Y.O, C.N., A.Q., K.Q., E.A.F); Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Champaign, Illinois (.J.A.); Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington (T.V.); and Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York (K.Q.)
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Edward A. Fisher
Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, New York (J.A., Y.O, C.N., A.Q., K.Q., E.A.F); Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Champaign, Illinois (.J.A.); Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington (T.V.); and Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York (K.Q.)
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Article Information

vol. 99 no. 3 175-183
DOI 
https://doi.org/10.1124/molpharm.120.000108
PubMed 
33384285

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 2, 2020
  • Accepted December 15, 2020
  • Published online February 11, 2021.

Article Versions

  • Earlier version (December 31, 2020 - 07:02).
  • You are viewing the most recent version of this article.
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Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jaume Amengual,
  2. Yoscar Ogando,
  3. Cyrus Nikain,
  4. Alexandra Quezada,
  5. Kun Qian,
  6. Tomas Vaisar, and
  7. Edward A. Fisher
  1. Leon H. Charney Division of Cardiology, Department of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, New York (J.A., Y.O, C.N., A.Q., K.Q., E.A.F); Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Champaign, Illinois (.J.A.); Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington (T.V.); and Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, New York (K.Q.)
  1. Address correspondence to:
    Dr. Edward A Fisher, Leon H. Charney Professor of Cardiovascular Medicine, Department of Medicine at New York University Grossman School of Medicine, 530 1st Ave., New York, NY 10016. E-mail: Edward.Fisher{at}nyulangone.org
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Molecular Pharmacology: 99 (3)
Molecular Pharmacology
Vol. 99, Issue 3
1 Mar 2021
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Research ArticleArticle

ACAT Inhibition and APOA1 Promote Atherosclerosis Resolution

Jaume Amengual, Yoscar Ogando, Cyrus Nikain, Alexandra Quezada, Kun Qian, Tomas Vaisar and Edward A. Fisher
Molecular Pharmacology March 1, 2021, 99 (3) 175-183; DOI: https://doi.org/10.1124/molpharm.120.000108

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Research ArticleArticle

ACAT Inhibition and APOA1 Promote Atherosclerosis Resolution

Jaume Amengual, Yoscar Ogando, Cyrus Nikain, Alexandra Quezada, Kun Qian, Tomas Vaisar and Edward A. Fisher
Molecular Pharmacology March 1, 2021, 99 (3) 175-183; DOI: https://doi.org/10.1124/molpharm.120.000108
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