Molecular Pharmacology: 99 (4)

April 01, 2021; Volume 99,Issue 4

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Arrestin-Dependent and -Independent Internalization of G Protein–Coupled Receptors: Methods, Mechanisms, and Implications on Cell Signaling
Ee Von Moo, Jeffrey R. van Senten, Hans Bräuner-Osborne and Thor C. Møller

Molecular Pharmacology April 2021, 99 (4) 242-255; DOI: https://doi.org/10.1124/molpharm.120.000192
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The Emerging Role of Neuronal Organoid Models in Drug Discovery: Potential Applications and Hurdles to Implementation
Laura A. Struzyna and Marla L. Watt

Molecular Pharmacology April 2021, 99 (4) 256-265; DOI: https://doi.org/10.1124/molpharm.120.000142

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Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone
Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan and Eric Chun Yong Chan

Molecular Pharmacology April 2021, 99 (4) 266-276; DOI: https://doi.org/10.1124/molpharm.120.000086
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A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity
Melanie Tran, Jianguo Wu, Li Wang and Dong-Ju Shin

Molecular Pharmacology April 2021, 99 (4) 277-285; DOI: https://doi.org/10.1124/molpharm.120.000117
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Chronic Exposure to SCO-267, an Allosteric GPR40 Full Agonist, Is Effective in Improving Glycemic Control in Rats
Ryokichi Koyama, Mitsugi Ookawara, Masanori Watanabe and Yusuke Moritoh

Molecular Pharmacology April 2021, 99 (4) 286-293; DOI: https://doi.org/10.1124/molpharm.120.000168
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Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors
Fabio Alejandro Aguilar Mora, Nshunge Musheshe, Asmaa Oun, Manon Buist-Homan, Frank Lezoualc’h, Xiaodong Cheng, Martina Schmidt and Han Moshage

Molecular Pharmacology April 2021, 99 (4) 294-307; DOI: https://doi.org/10.1124/molpharm.120.000217