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Molecular Pharmacology

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Research ArticleArticle

Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target NaV1.7

Julie K Klint, Yanni K. Y. Chin and Mehdi Mobli
Molecular Pharmacology October 1, 2015, mol.115.100784; DOI: https://doi.org/10.1124/mol.115.100784
Julie K Klint
The University of Queensland
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Yanni K. Y. Chin
The University of Queensland
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Mehdi Mobli
The University of Queensland
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  • Data Supplement

    Files in this Data Supplement:

    • Supplemental Figures -

      Supplemental Figure 1 - Expression and purification of wild-type Hhn2b

      Supplemental Figure 2 - Wild-type recombinant Hhn2b has no or little effect on human NaV channels

      Supplemental Figure 3 - Overlay of the 2D 1H-15N-HSQC spectra of WT, N24S and G7W/N24S mutants of Hhn2b

      Supplemental Figure 4 - 15N-NOESY strips showing the intramolecular NOE signals of the beta-protons of Asp27 in WT, N24S and G7W/N24S mutants of Hhn2b

      Supplemental Figure 5 - NH region of 1D 1H-NMR spectra of Hhn2b (WT) and mutants in the presence of excess amount of POPC liposomes

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Molecular Pharmacology: 101 (6)
Molecular Pharmacology
Vol. 101, Issue 6
1 Jun 2021
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Research ArticleArticle

Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target NaV1.7

Julie K Klint, Yanni K. Y. Chin and Mehdi Mobli
Molecular Pharmacology October 1, 2015, mol.115.100784; DOI: https://doi.org/10.1124/mol.115.100784

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Research ArticleArticle

Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target NaV1.7

Julie K Klint, Yanni K. Y. Chin and Mehdi Mobli
Molecular Pharmacology October 1, 2015, mol.115.100784; DOI: https://doi.org/10.1124/mol.115.100784
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