Data Supplement

Files in this Data Supplement:

• Supplemental Figures -

  Supplemental Figure 1 - Expression and purification of wild-type Hhn2b

  Supplemental Figure 2 - Wild-type recombinant Hhn2b has no or little effect on human NaV channels

  Supplemental Figure 3 - Overlay of the 2D 1H-15N-HSQC spectra of WT, N24S and G7W/N24S mutants of Hhn2b

  Supplemental Figure 4 - 15N-NOESY strips showing the intramolecular NOE signals of the beta-protons of Asp27 in WT, N24S and G7W/N24S mutants of Hhn2b

  Supplemental Figure 5 - NH region of 1D 1H-NMR spectra of Hhn2b (WT) and mutants in the presence of excess amount of POPC liposomes