Article Figures & Data
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Data Supplement
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- Supplemental Data -
Supplemental Figure 1 - Competition kinetic binding to determine the kinetic rate constants of unlabeled compounds
Supplemental Figure 2 - Effect of CRTh2 antagonists on PGD2 stimulated GTP-gamma-S accumulation
Supplemental Figure 3 - Effect of increasing concentrations of CRTh2 antagonist...
Supplemental Figure 4 - Estimation of the dissociation rate of the CRTh2 antagonist QAW039 from functional 35S-GTP-gamma-S data...
Supplemental Figure 5. Association of 3H-QAW039 and 3H-OC-459 at room temperature to the human CRTh2receptor expressed in membranes from CHO cells
Supplemental Table 1 - Fitted affinity estimates for CRTh2 antagonism of PGD2 stimulated 35S-GTP-gamma-S accumulation
Supplemental Table 2 - Fitted parameter estimates for QAW039 mediated antagonism of PGD2 stimulated 35S-GTP-gamma-S accumulation according to an operational hemi-equilibrium model for competitive antagonism (Kenakin, 2009)
Supplemental Table 3 - Kinetic parameters of 3H-QAW039 and OC-459 at the human CRTh2 receptor measured at room temperature
Supplemental method
Supplemental Figure 6 - Structures and positions of tritium labelling in 3H9OC459 (1) and 3H3QAW039 (2)
Supplemental Figure 6. Structures and positions of tritium labelling in 3H9OC459 (1) and 3H3QAW039 (2). References
- Supplemental Data -