Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplemental Figure 1 - General synthetic scheme for the analog synthesis

  Supplemental Figure 2 - Combined steric and electronic features of retigabine and new KCNQ2/3- specific channel activators, illustrating the effects of fluorinations on the aromatic rings and their substituents

  Supplemental Table 1 - Summary values of EC50 and maximal (Max) ΔV1/2 for all compounds tested

  Detailed values for main figures