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Research ArticleArticle

Synthesis and Evaluation of Potent KCNQ2/3-specific Channel Activators

Manoj Kumar, Nicholas Reed, Ruiting Liu, Elias Aizenman, Peter Wipf and Thanos Tzounopoulos
Molecular Pharmacology March 22, 2016, mol.115.103200; DOI: https://doi.org/10.1124/mol.115.103200
Manoj Kumar
University of Pittsburgh
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Nicholas Reed
University of Pittsburgh
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Ruiting Liu
University of Pittsburgh
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Elias Aizenman
University of Pittsburgh
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Peter Wipf
University of Pittsburgh
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Thanos Tzounopoulos
University of Pittsburgh
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      Supplemental Figure 1 - General synthetic scheme for the analog synthesis

      Supplemental Figure 2 - Combined steric and electronic features of retigabine and new KCNQ2/3- specific channel activators, illustrating the effects of fluorinations on the aromatic rings and their substituents

      Supplemental Table 1 - Summary values of EC50 and maximal (Max) ΔV1/2 for all compounds tested

      Detailed values for main figures

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Molecular Pharmacology: 103 (2)
Molecular Pharmacology
Vol. 103, Issue 2
1 Feb 2023
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Research ArticleArticle

Synthesis and Evaluation of Potent KCNQ2/3-specific Channel Activators

Manoj Kumar, Nicholas Reed, Ruiting Liu, Elias Aizenman, Peter Wipf and Thanos Tzounopoulos
Molecular Pharmacology March 22, 2016, mol.115.103200; DOI: https://doi.org/10.1124/mol.115.103200

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Research ArticleArticle

Synthesis and Evaluation of Potent KCNQ2/3-specific Channel Activators

Manoj Kumar, Nicholas Reed, Ruiting Liu, Elias Aizenman, Peter Wipf and Thanos Tzounopoulos
Molecular Pharmacology March 22, 2016, mol.115.103200; DOI: https://doi.org/10.1124/mol.115.103200
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