Data Supplement

• Supplemental Data -

  Supplemental Table 1 - DNA-encoded libraries used in screening
  
  Supplemental Figure 1 - Preparation of the agonist-occupied β2AR in HDL particles and analysis of primary 50 candidates
  
  Supplemental Figure 2 - Cmpd-6-mediated enhancement of cAMP production in the β2AR overexpressed system
  
  Supplemental Figure 3 - Additional data showing positive allosteric activity of Cmpd-6 and -43 for othosteric ligand binding to the β2AR
  
  Supplemental Figure 4 - Cmpd-6 binding to the β2AR does not block Nb80 binding to the intracellular pocket of the receptor
  
  Supplemental Figure 5 - Specificity of Cmpd-6 for the β2AR
  
  Supplemental Figure 6 - Cmpd-6-mediated increases in β2AR activation by stimulation with a range of other agonists