Data Supplement

• Supplemental Data -

  Supplemental Figure 1. Crystal contacts forming the biological GGPPS assembly
  

  Supplemental Figure 2. Thermal shift assay
  

  Supplemental Figure 3. Zoledronate omit map
  

  Supplemental Figure 4. Three Mg2+ ions are involved in zoledronate binding
  

• PDB 1 -

  Data Supplement 1 - Crystal structure of zoledronate-bound GGPPS-D188Y (PDB 6G31)
  

• PDB 2 -

  Data Supplement 2 - Crystal structure of apo GGPPS-D188Y (PDB 6G32)
  
  

• PDB 3 -

  Data Supplement 3 - Re-refinement of zoledronate-bound yeast GGPPS (PDB 2E91)