Article Figures & Data
Additional Files
Data Supplement
- Supplemental Figures -
Supplemental Figure 1 - Effects of Sp1 and NF-Y on the mRNA level of human CYP3A in QSG-7701 and HepaRG cell lines.
Supplemental Figure 2 - Sp1 overexpression in human hepatocytes increased the mRNA expression levels of CYP3A4 and CYP3A5.
Supplemental Figure 3 - Effects of Sp1 on the protein level of pCYP3A in porcine primary hepatocytes.
Supplemental Figure 4 - Nucleotide variations in the cis-acting elements affected the contributions of these elements to the basal transcription level of CYP3A22.
Supplemental Figure 5 - Both NF-Y and Sp1 activate CYP3A5 and CYP3A4 transcription by binding to the proximal CCAAT box and GC box in human hepatocytes.
Supplemental Figure 6 - Coordinated regulation of human CYP3A4 and CYP3A5 by NF-Y and Sp1 in human hepatocytes.
- Supplemental Figures -