Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplementary Figure 1 - Sequence alignment of AncGR2 LBD and hGR LBD.
Supplementary Figure 2 - Detailed structure comparison between DEX and HCY bound to GR.
Supplementary Figure 3 - Overall structure comparison between AncGR2 LBD bound to DEX and HCY.
Supplementary Figure 4 - Sequence map of peptic fragments identified in HDX-MS show 96 % coverage of AncGR2 LBD.
Supplementary Figure 5 - Cα root mean square deviations (RMSDs) during simulations of AncGR2 LBD in complex with glucocorticoid ligands DEX and HCY (A) and coactivators Tif2 and PGC1α (B).
Supplementary Figure 6 - Structural overlay of AncGR2 LBD-PGC1α and PPARγ LBD-PGC1α complexes.
- Supplemental Data -
Supplementary Data - Structure of the AncGR2 LBD in complex with DEX and PGC1α.
- Supplemental Data -
Supplementary Data - Structure of the AncGR2 LBD in complex with HCY and PGC1α.
- Supplemental Data -