Enhancement of muscimol binding and gating by allosteric modulators of the GABAA receptor: relating occupancy to state functions

Gustav Akk; Allison L. Germann; Yusuke Sugasawa; Spencer R. Pierce; Alex S. Evers; Joseph Henry Steinbach

doi:10.1124/molpharm.120.000066

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Enhancement of muscimol binding and gating by allosteric modulators of the GABA_A receptor: relating occupancy to state functions

Gustav Akk, Allison L. Germann, Yusuke Sugasawa, Spencer R. Pierce, Alex S. Evers and Joseph Henry Steinbach

Molecular Pharmacology July 28, 2020, MOLPHARM-AR-2020-000066; DOI: https://doi.org/10.1124/molpharm.120.000066

Gustav Akk

1Anesthesiology, Washington University School of Medicine, United States

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For correspondence: akk@morpheus.wustl.edu

Allison L. Germann

1Anesthesiology, Washington University School of Medicine, United States

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Yusuke Sugasawa

1Anesthesiology, Washington University School of Medicine, United States

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Spencer R. Pierce

1Anesthesiology, Washington University School of Medicine, United States

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Alex S. Evers

2Anesthesiology and Pharmacology, Washington University School of Medicine, United States of America

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Joseph Henry Steinbach

3Dept. of Anesthesiology, Washington University School of Medicine, United States of America

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Molecular Pharmacology

Vol. 99, Issue 3

1 Mar 2021

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