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Proteomic approaches to investigate regulated trafficking and signaling of GPCRs

Mark von Zastrow
Molecular Pharmacology December 22, 2020, MOLPHARM-MR-2020-000178; DOI: https://doi.org/10.1124/molpharm.120.000178
Mark von Zastrow
1Departments of Psychiatry and Pharmacology, University of California, San Francisco, United States of America
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  • For correspondence: mark.vonzastrow@ucsf.edu
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Abstract

Advances in proteomic methodologies based on quantitative mass spectrometry are now transforming pharmacology and experimental biology more broadly. The present review will discuss several examples, based on work in the author's laboratory that focuses on delineating relationships between GPCR signaling and trafficking in the endocytic network. The examples highlighted correspond to those discussed in a talk presented at the 2019 EB/ASPET meeting, organized by Professor Joe Beavo to commemorate his receipt of the Julius Axelrod Award.

Significance Statement This is a review related to the EB2019 Axelrod Symposium.

  • g protein-coupled receptors (GPCRS)
  • phosphorylation
  • proteomics
  • Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 99 (2)
Molecular Pharmacology
Vol. 99, Issue 2
1 Feb 2021
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Proteomic analysis of GPCR cell biology

Mark von Zastrow
Molecular Pharmacology December 22, 2020, MOLPHARM-MR-2020-000178; DOI: https://doi.org/10.1124/molpharm.120.000178

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OtherMinireview

Proteomic analysis of GPCR cell biology

Mark von Zastrow
Molecular Pharmacology December 22, 2020, MOLPHARM-MR-2020-000178; DOI: https://doi.org/10.1124/molpharm.120.000178
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