Data Supplement

• Supplemental Figures -

  Supplemental Figure 1 - Overlap in the regulation of gene expression by formoterol and budesonide in BEAS-2B cells.

  Supplemental Figure 2 - Effect of budesonide on formoterol-induced gene expression and of formoterol on budesonide-induced gene expression.

  Supplemental Figure 3 - Functional annotation clustering of the genes induced by formoterol or budesonide showing effects of formoterol + budesonide in BEAS-2B cells.

  Supplemental Figure 4 - Overall GO analysis of genes induced by formoterol, budesonide or budesonide plus formoterol in BEAS-2B cells.

  Supplemental Figure 5 - Functional annotation clustering of the genes repressed by formoterol or budesonide showing the effect of formoterol + budesonide in BEAS-2B cells.

  Supplemental Figure 6 - Overall GO analysis of genes repressed by formoterol, budesonide or budesonide plus-formoterol in BEAS-2B cells.

  Supplemental Figure 7 - GO analysis for all genes modulated by formoterol, budesonide and budesonide-plus-formoterol in BEAS-2B cells.

  Supplemental Figure 8 - Overall GO analysis of all genes modulated by formoterol, budesonide and budesonide-plus-formoterol in pHBE cells.
  

• Supplemental Table 1 -

  Supplemental Table 1 -  Genes meeting the threshold for modulation by formoterol, budeson or budesonide plus formoterol in BEAS-2B cells.
  

  
  

• Supplemental Table 2 -

  Supplemental Table 2 - Supra - and infra -additivity between formoterol and budesonide in BEAS-2B cells.
  

• Supplemental Table 3 -

  Supplemental Table 3 - Enhanced repression of expression by combination treatment in BEAS-2B cells. 
  

• Supplemental Table 4 -

  Supplemental Table 4 - Comparative GO enriched (P _B ≤0.05) with the genes modulated, up or down, by formoterol, budesonide or the combination in BEAS-2B cells.
  
  
  

• Supplemental Table 5 -

  Supplemental Table 5 -  Genes meeting the threshold for modulation by formoterol, budesonide or budesonide plus formoterol in pHBECs.
  

• Supplemental Table 6 -

  Supplemental Table 6 - Comparative GO enriched with the genes modulated, up or down, by formoterol, budesonide or the combination in pHBECs.