Data Supplement

• Supplemental Data  -

  Supplemental Methods

  Supplemental Figure 1 - Immunocytochemical staining of cytosolic and mitochondrial localized apoaequorin.

  Supplemental Figure 2 - Aequorin-mediated luminescence signal of HEK293 cells depends on the expression of CNGA3.
  

  Supplemental Figure 3 - Comparison of fold changes obtained with CNGA3WT and CNGA3E228K after treatment with five dihydropyridines.
  

  Supplemental Figure 4 -Graphical representation of the FC_max and the concentration necessary to reach FC_max for the compounds of the pyrazine amide and benzamide class
  

  Supplemental Table 1 - Summary of the measured fold changes (FC) of compounds analyzed with the bioassay. 
  

  Supplemental Table 2 - Summary of compounds tested for determining structure-activity relationship of the dihydropyridine (DHP) compound class.
  

  Supplemental Table 3 - Molecular structure of the additionally tested dihydropyridine (DHP) derivates.