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Molecular Pharmacology

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Senolytic-mediated elimination of head and neck tumor cells induced into senescence by cisplatin

Fereshteh Ahmadinejad, Tasia Bos, Bin Hu, Erin Britt, Jennifer Koblinski, Andrew J Souers, Joel D. Leverson, Anthony C. Faber, David A. Gewirtz and Hisashi Harada
Molecular Pharmacology December 14, 2021, MOLPHARM-AR-2021-000354; DOI: https://doi.org/10.1124/molpharm.121.000354
Fereshteh Ahmadinejad
1Human and Molecular Genetics, Virginia Commonwealth University, United States
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Tasia Bos
2Virginia Commonwealth University, United States
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Bin Hu
2Virginia Commonwealth University, United States
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Erin Britt
2Virginia Commonwealth University, United States
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Jennifer Koblinski
2Virginia Commonwealth University, United States
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Andrew J Souers
3Abbvie, United States
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Joel D. Leverson
4AbbVie, United States
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Anthony C. Faber
2Virginia Commonwealth University, United States
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David A. Gewirtz
5Dept. of Medicine, Virginia Commonwealth University, United States
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Hisashi Harada
6Massey Cancer Center, VCU, United States
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  • For correspondence: hharada@vcu.edu
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    • Supplemental Figures -

      Figure S1. Immunofluorescence imaging of C12FDG in A) HN30 and B) HN12 cells after senescence induction by 5 μM cisplatin. 

      Figure S2. ABT-263 has minimal cytotoxicity on non-senescent cells or proliferative
      recovering cells from senescence.

      Figure S3. BCL-XL is the primary target for ABT-263-induced senolysis.

      Figure S4. Cisplatin, ABT-263 treatment alone or in combination did not result in significant Neutropenia.

      Figure S5. Cisplatin, ABT-263 treatment alone or in combination did not result in significant levels of
      DNA double strand breaks measured by γ-H2AX levels. p > 0.05 All quantitative graphs are mean ± SD
      from at least three independent experiments.

      Figure S6. Animal experiments diagram.

    • Supplemental Video 1A -

      Video S1. Live cell imaging of A) Vehicle treated. Note that control cells are included to compare morphology and cellular behavior in between control and senescent cells




    • Supplemental Video 1B -

      Video S1. Live cell imaging of  B) 5 μM cisplatin-treated HN30 cells at Days 5-6. Note that control cells are included to compare morphology and cellular behavior in between control and senescent cells.

    • Supplemental Video 1C -

      Video S1. Live cell imaging of   C) Day 10-12 (recovered cells). Time lapse images of HN30 cells were
      taken with 15 min intervals. Note that control cells are included to compare morphology
      and cellular behavior in between control and senescent cells.

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Molecular Pharmacology: 103 (2)
Molecular Pharmacology
Vol. 103, Issue 2
1 Feb 2023
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OtherArticle

Recovery and elimination of senescent tumor cells

Fereshteh Ahmadinejad, Tasia Bos, Bin Hu, Erin Britt, Jennifer Koblinski, Andrew J Souers, Joel D. Leverson, Anthony C. Faber, David A. Gewirtz and Hisashi Harada
Molecular Pharmacology December 14, 2021, MOLPHARM-AR-2021-000354; DOI: https://doi.org/10.1124/molpharm.121.000354

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OtherArticle

Recovery and elimination of senescent tumor cells

Fereshteh Ahmadinejad, Tasia Bos, Bin Hu, Erin Britt, Jennifer Koblinski, Andrew J Souers, Joel D. Leverson, Anthony C. Faber, David A. Gewirtz and Hisashi Harada
Molecular Pharmacology December 14, 2021, MOLPHARM-AR-2021-000354; DOI: https://doi.org/10.1124/molpharm.121.000354
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